EFFECTS OF BARBITURATES ON THE DECEREBRATE RIGIDIIY IN RATS
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概要
- 論文の詳細を見る
Effects of barbiturates (phenobarbital, mephobarbital, pentobarbital, hexobarbital and amobarbital) on the tonic and phasic responses of forelimbs were studied in the rats in which rigidity was induced by means of anemic decerebration. The inhibitory pattern of the tonic and phasic responses to phenobarbital was different from those to the other barbiturates, i.e. phenobarbital gradually inhibited both tonic and phasic responses, whereas other barbiturates suppressed significantly only the tonic response immediately after the administration of a relatively low dose (10 mg/kg) but hardly inhibited the phasic response unless at higher doses (20 and 40 mg/kg). Possible involvement of GABA-system in the inhibitory action of phenobarbital and pentobarbital on the rigidity was investigated. Since inhibition of the phasic response to pentobarbital was potentiated by the pretreatment of animals with carboxymethoxylamine hemihydrochloride (AOAA) and suppressed by the pretreatment with semicarbazide, it was suggested that GABAergic mechanism may be involved in the particular inhibition of phasic response to pentobarbital. However, the inhibitory action of phenobarbital appeared to be independent of GABA-system.
- 公益社団法人日本薬学会の論文
著者
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Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kondo Mitsuru
Department Of Synthetic Chemistry And Biological Chemistry Graduate School Of Engineering Kyoto Univ
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FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
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Kondo Mitsuru
Department Of Chemistry Faculty Of Science Shizuoka University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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Kondo Mitsuru
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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GOTO Masayoshi
Department of Biological Science, Research and Development Laboratories, Hoechst Japan Limited
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