POSTNATAL DEVELOPMENT OF THE GABA SYSTEM IN THE RAT SPINAL CORD
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概要
- 論文の詳細を見る
To assess the postnatal development of the GABA system in the rat spinal cord, GABA levels and GAD activity, as well as specific [<SUP>3</SUP>H]-muscimol binding, were determined in the dorsal and ventral areas. GABA levels and GAD activities did not vary in parallel from 1 to 8 postnatal days since the former decreased and the latter increased. After 8 days, however, increases in GABA levels and GAD activities were observed in tissues from the dorsal area and decreases were observed in tissues from the ventral area. Specific [<SUP>3</SUP>H]muscimol binding was unexpectedly high in both areas at 1 and 8 days but decreased linearly up to 22 days. Our findings show that there are distinct differences in the development of the GABA system in the rat spinal cord and brain.
- 社団法人 日本薬理学会の論文
著者
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Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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