Effect of Oral Treatment of Perilla frutescens and Its Constituents on Type-I Allergy in Mice
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概要
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Perilla frutescens BRITTON (perilla, Labiatae) is a medicinal herb prescribed in Saiboku-to (柴朴湯), which is a Kampo formula effective for allergic diseases such as bronchial asthma. The present study was conducted to evaluate the anti-allergic effect of orally administered perilla decoction and to identify the active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction, which is one of the animal models for type I allergy. Perilla decoction significantly suppressed PCA-reaction, and the inhibition % at the dose of 500 mg/kg was 43%. The perilla decoction contains 5.3% of luteolin 7-O-[β-glucuronosyl(2→1)β-glucuronide], 1.6% of apigenin 7-O-[β-glucuronosyl(2→1)β-glucuronide], 0.49% of scutellarin, and 2.5% of rosmarinic acid (weight of compound/dried weight of perilla decoction %), respectively. When these constituents were orally administered to mice at the dose equivalent to 500 mg/kg of perilla decoction, rosmarinic acid and apigenin 7-O-[β-glucuronosyl(2→1)β-glucuronide] significantly suppressed PCA-reaction, and their inhibition % was 41% (p<0.01) and 32% (p<0.05), respectively. Since the inhibition % or perilla decoction and rosmarinic acid were nearly equal, the anti-allergic effect of perilla decoction depends primarily on rosmarinic acid. The standard Saiboku-to decoction contained 0.013% of rosmarinic acid, which was too low to exhibit anti-allergic activity in a daily dose of Saiboku-to in adults, suggesting that perilla would be prescribed in Saiboku-to to exhibit other pharmacological effects than its anti-allergic activity, such as a sedative.
- 2001-10-01
著者
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Fujii Hajime
Research And Development Division Amino Up Chemical Co. Ltd.
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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WAKUSHIMA Hannosuke
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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FURUTA Yasuyuki
Department of Kampo Medicinal Sciences, Hokkaido College of Pharmacy
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NAKAGAWA Takashi
Research and Development Division, Amino Up Chemical Co., Ltd.
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Makino Toshiaki
R&d Division Sunstar Inc.
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Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
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Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Furuta Y
Department Of Kampo Medicinal Sciences Hokkaido College Of Pharmacy
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Wakushima Hannosuke
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
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Makino Taketoshi
R&d Center Sunstar Inc.
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Makino Toshiaki
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Nakagawa Takashi
Research And Development Division Amino Up Chemical Co. Ltd.
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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