CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A_1,A_2 AND B_2)
スポンサーリンク
概要
- 論文の詳細を見る
Prostaglandins A_1,A_2 and B_2 (PG A_1,A_2 and B_2) dose-dependently inhibited specific [^3H] diazepam binding to rat brain membranes but did not affect specific [^3H]Ro 5-4864 binding to kidney membranes. The inhibition of [^3H] diazepam binding to brain membranes by benzodiazepine agonists (diazepam and flurazepam) was potentiated by 30 μM GABA, whereas those of prostaglandins were not modified by the same concentration of GABA. These results suggest that PG A_1,A_2 and B_2 specifically interact with central type-benzodiazepine receptors in a manner different from interactions seen with benzodiazepine agonists.
- 社団法人日本薬学会の論文
著者
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
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Fukuda H
Department Of Pharmacology College Of Pharmacy Nihon University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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Matsumoto Kinzo
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Saito Ken-ichi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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