EFFECT OF BACLOFEN ON THE γ-MOTOR ACTIVITY IN THE RAT
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概要
- 論文の詳細を見る
The effect of baclofen on static γ-activity enhanced by pinna pinching was compared with some of centrally acting muscle relaxants (chlorpromazine, mephenesin and diazepam) in the anesthetized rat. Baclofen (0.5-2 mg/kg, i.v.) showed only a little effect on the static γ-activity. At a higher dose of 5 mg/kg, the drug showed a marked depressant effect on the static γ-activity, although this dose was much higher than that required to depress spinal reflex activity. On the other hand, chlorpromazine, mephenesin and diazepam depressed the static γ-activity at lower doses than those required to depress spinal reflex activity. From these results, it is concluded that the depressant action of baclofen on the static γ-activity has only a little contribution to the muscle relaxant action and therapeutic effectiveness of the drug.
- 公益社団法人日本薬学会の論文
著者
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FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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KUDO YOSHIHISA
Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology an
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Kudo Yoshihisa
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University:(prese
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TAKEUCHI ERIKO
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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Takeuchi Eriko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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