Enhancement of Spinal Monosynaptic Reflexes with Phenylethylamine and Related Drugs through Descending Noradrenergic Neurons
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概要
- 論文の詳細を見る
The effects of phenylethylamine (PEA) and related drugs, such as methamphetamine, phenelzine, methylphenidate, nomifensine and mazindol on the spinal monosynaptic reflex (MSR) were investigated in rats treated with 6-hydroxydopamine (6-OHDA) or 5,6-dihydroxytryptamine (5,6-DHT). PEA (1×10^<-5>mol/kg, i.v.) increased the amplitude of MSR in control rats, but decreased the amplitude in rats treated with 6-OHDA. Although PEA-related drugs increased the amplitude of MSR, they did not change the MSR amplitude in 6-OHDA-treated rats. In 5,6-DHT-treated rats, PEA-related drugs increased the amplitude of MSR, whereas PEA produced a decrease. These results support our previous suggestion that the enhancement of MSR by these drugs might be mediated through release of noradrenaline or inhibition of noradrenaline uptake at the noradrenergic synapses.
- 公益社団法人日本薬学会の論文
著者
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OHTA Shigeru
Department of Pediatrics, Matsue Red Cross Hospital
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FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
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Fukuda H
Department Of Pharmacology College Of Pharmacy Nihon University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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ONO HIDEKI
Department of Pharmacy, Branch Hospital, the University of Tokyo
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HASEBE YASUSHI
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tok
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HIROBE Masaaki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Ohta S
Univ. Tokyo Tokyo Jpn
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HIROBE Masaaki
Department of Bioorganic and Medicinal Chemistry
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Ohta Shigeru
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Hirobe M
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Hasebe Y
Saitama Inst. Technol. Saitama Jpn
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Hasebe Y
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Hasebe Yasushi
Department Of Applied Chemistry Faculty Of Engineering Saitama Institute Of Technology
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Ohta Shigeru
Department Of Bioorganic And Medicinal Chemistry Faculty Of Pharmaceutical Sciences University Of To
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Ono Hideki
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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