EFFECTS OF EPOXIDES OF HEROIN, MORPHINE AND CODEINE ON THE ELECTRICALLY STIMULATED GUINEA PIG ILEUM
スポンサーリンク
概要
- 論文の詳細を見る
Modes of action of codeine epoxide, a new metabolite of codeine, and epoxides of morphine and heroin on the electrically stimulated guinea pig ileum were studied. The opiates and their epoxides inhibited the twitch response of the ileum to electrical stimulation. The inhibitory actions of the test drugs were antagonized by naloxone. The activities of epoxides were not strikingly different from those of the parent opiates. Dependence liabilities of the epoxides were also tested on the guinea pig ileum which was treated with a high concentration of the test drugs. Epoxydation of 7, 8-double bond in the parent opiates showed a trend toward a decrease in dependence liability.
- 社団法人 日本薬理学会の論文
著者
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Miyata Naoki
Department of Organic & Medicinal Chemistry, Nagoya City University, Graduate School of Pharmaceutic
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HIROBE Masaaki
Department of Bioorganic and Medicinal Chemistry
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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WATANABE Keizo
Department of Polymer Science and Engineering, Kyoto Institute of Technology
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UBA Kiyoko
Department of Bioorganic and Medicinal chemistry, Faculty of Pharmaceutical Sciences, University of
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Miyata Naoki
Department Of Bioorganic And Medicinal Chemistry Faculty Of Pharmaceutical Sciences University Of To
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Watanabe Keizo
Department Of Polymer Science And Engineering Kyoto Institute Of Technology
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MIYATA NAOKI
Department of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
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HIROBE MASAAKI
Department of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
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WATANABE Keizo
Department of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
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