Nitration of Specific Tyrosine Residues of Cytochrome c Is Associated with Caspase-Cascade Inactivation(Biochemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Peroxynitrite, a potent oxidative stress inducer, inhibits the mitochondrial electron transfer, induces cell death, and is considered to be involved in the pathology of various diseases. However, the intracellular mechanisms involved in the cell death process are not fully understood. Here we demonstrate that the enhanced nitration of specific tyrosine residues of cytochrome c, which are induced by continuous peroxynitrite exposure, attenuates cytochrome c-induced caspase-9 activation in vitro. Interestingly, cytochrome c nitrated with a single high dose of peroxynitrite preserved its potency, while this did not occur when cytochrome c was treated with continuous peroxynitrite exposure. Although both of these experiments resulted in cytochrome c nitration at the tyrosine residues, it was found that nitration at specific residues was enhanced only when cytochrome c was exposed to continuous peroxynitrite. This is the first report to demonstrate that cytochrome c nitration affects the apoptotic pathway by means of enhancement of nitration at specific tyrosine residues. This result implies that the nitration pattern of cytochrome c may affect the efficacy of the mitochondrial pathway in apoptotic cell death.
- 公益社団法人日本薬学会の論文
- 2007-01-01
著者
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宮田 直樹
名古屋市立大学
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宮田 直樹
名市大薬
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伊古田 暢夫
放射線医学総合研究所
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OZAWA Toshihiko
Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo
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IKOTA Nobuo
Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo
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IKOTA Nobuo
School of Pharmacy, Shujitsu University
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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Ishigure Nobuhito
Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)
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OZAWA Toshihiko
Department of Health Pharmacy, Yokohama College of Pharmacy
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Miura Yuri
Tokyo Metropolitan Inst. Of Gerontology Tokyo Jpn
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Miura Yuri
Tokyo Metropolitan Institute Of Gerontology
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Ikota Nobuo
Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences
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Toda Tosifusa
Tokyo Metropolitan Institute Of Gerontology
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Ishii Nobuyuki
Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)
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Ikota Nobuo
Redox Regulation Research Group National Institute Of Radiological Sciences
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TAKUSAGAWA Mitsuko
Redox Regulation Research Group, National Institute of Radiological Sciences
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Miyata Naoki
Department of Organic & Medicinal Chemistry, Nagoya City University, Graduate School of Pharmaceutic
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NAKAGAWA HIDEHIKO
Department of Laboratory Medicine, Miyazaki Medical College
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Ozawa Toshihiko
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Ozawa Toshihiko
Redox Regulation Research Group National Institute Of Radiological Sciences
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Nakagawa Hidetoshi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Ozawa Toshihiko
放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ
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KOMAI Nobuko
Redox Regulation Research Group, National Institute of Radiological Sciences
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Nakagawa H
Mukogawa Women's Univ. Nishinomiya Jpn
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Komai Nobuko
Redox Regulation Research Group National Institute Of Radiological Sciences
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Nakagawa Hidehiko
Department Of Laboratory Medicine Miyazaki Medical College
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Nakagawa Hiroshi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Nakagawa Hidehiko
Department Of Organic And Medicinal Chemistry Graduate School Of Pharmaceutical Sciences Nagoya City
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Miyata Naoki
Department Of Bioorganic And Medicinal Chemistry Faculty Of Pharmaceutical Sciences University Of To
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Takusagawa Mitsuko
Redox Regulation Research Group National Institute Of Radiological Sciences
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