In Vivo Radioprotection of Mice by 3-Methyl-1-phenyl-2-pyrazolin-5-one (Edaravone; Radicut^[○!R]), a Clinical Drug

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概要

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• Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut^[○!R]) is a brain-protecting agent used clinically to treat acute ischemic stroke with a reaction mechanism of free radical scavenging. Since the initial stage of radiation damage involves the formation of free radicals, edaravone is expected to be effective in preventing lethal damage from ionizing radiation. In the present study, we used mice to examine in vivo the radioprotective effect of edaravone on whole body X-ray irradiation. A solution of edaravone was administered intraperitoneally to C3H mice (male, 10 weeks old), and they were irradiated with a total dose of 8.0 Gy. Edaravone exhibited dose-dependent and injection time-dependent radioprotection. When injected 30min before the X-ray irradiation, it had the greatest radioprotective effect, whereas an injection after the irradiation showed no protective effect. The LD_<50/30> was about 8.8 Gy for edaravone-injected mice and 6.6 Gy for control mice, yielding a DRF for edaravone (450mg/kg bw) of 1.3. Edaravone decreased the body temperature transiently about 3-6℃, but this did not seem to be responsible for the radioprotection. Since the radioprotection was observed only when the reagent was administered before the irradiation, the primary action of edaravone might be the quenching of free radicals with a short lifetime generated by the irradiation.

• 2004-06-15

著者

• 伊古田 暢夫

  放射線医学総合研究所

• ANZAI Kazunori

  Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo

• IKOTA Nobuo

  Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiolo

• IKOTA Nobuo

  School of Pharmacy, Shujitsu University

• 伊古田 暢夫

  放射線医学総合研究所重粒子医科学センター

• FURUSE Masako

  Redox Regulation Research Group, National Institute of Radiological Sciences

• YOSHIDA Akira

  Redox Regulation Research Group, National Institute of Radiological Sciences

• MATSUYAMA Azusa

  Redox Regulation Research Group, National Institute of Radiological Sciences

• MORITAKE Takashi

  Redox Regulation Research Group, National Institute of Radiological Sciences

• TSUBOI Koji

  Institute of Clinical Medicine, University of Tsukuba

• Ishigure Nobuhito

  Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)

• Ikota Nobuo

  Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences

• Furuse Masako

  Redox Regul. Res. Group Natl. Inst. Radiol. Sci.

• Furuse Masako

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Anzai Kazunori

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Tsuboi Koji

  Institute Of Clinical Medicine University Of Tsukuba

• Ishii Nobuyuki

  Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)

• Ikota Nobuo

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Matsuyama Azusa

  Redox Regulation Research Group National Institute Of Radiological Sciences

• Moritake Takashi

  Redox Regulation Research Group National Institute Of Radiological Sciences:institute Of Clinical Me

• Yoshida A

  Toyohashi Univ. Technol. Toyohashi Jpn

• Anzai Kazunori

  Redox Regulation Research Group, National Institute of Radiological Sciences

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