Heat-Treated Mineral-Yeast as a Potent Post-irradiation Radioprotector
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概要
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In vivo radioprotection of OH mice by i.p. administration of Zn-, Mn-, Cu-, or Se-containing heat-treated Saccharomyces serevisiae yeast sample was examined. The 30-day survival of the group treated 30 min before 7.5 Gy whole-body X-irradiation with mineral-containing yeast powders suspended in 0.5% methylcellulose was significantly higher than that of control group. When mineral-yeast was administered immediately after irradiation, the survival rate was even higher and Zn- or Cu-yeast showed the highest rate (more than 90%). Although treatment with simple yeast showed a high survival rate (73%), it was significantly lower than that obtained by the Zn-yeast treatment. The effects of Zn-yeast were studied further. When the interval between irradiation and administration was varied, the protective activity of Zn-yeast decreased gradually by increasing the interval but was still significantly high for the administration at 10 h post-irradiation. The dose reduction factor of Zn-yeast (100 mg/kg, i.p. administration immediately after irradiation) was about 1.2. When the suspension of Zn-yeast was fractionated by centrifugation, the insoluble fraction showed a potent effect, while the soluble fraction had only a moderate effect. In conclusion, mineral-yeast, especially Zn-yeast, provides remarkable post-irradiation protection against lethal whole body X-irradiation. The activity is mainly attributable to the insoluble fraction, whereas some soluble components might contribute to the additional protective activity.
- 日本放射線影響学会の論文
- 2008-07-16
著者
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ANZAI Kazunori
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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伊古田 暢夫
放射線医学総合研究所
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IKOTA Nobuo
School of Pharmacy, Shujitsu University
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伊古田 暢夫
放射線医学総合研究所重粒子医科学センター
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Ishigure Nobuhito
Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)
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KAGIYA Tsutomu
Health Research Foundation
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Ikota Nobuo
Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences
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Anzai Kazunori
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Anzai Kazunori
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Anzai Kazunori
Department Of Bioregulation Research National Institute Of Radiological Sciences
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Kagiya Tsutomu
Health Res. Foundation Kinki Invention Centre
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Ishii Nobuyuki
Env. Toxic. Sci. Cent. Radiat. Safety Nat. Inst. Rad. Sci.(nirs)
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Ikota Nobuo
Redox Regulation Research Group National Institute Of Radiological Sciences
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UENO Megumi
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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NYUI Minako
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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Ueno Megumi
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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Nyui Minako
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Nyui Minako
Research Center For Charged Particle Therapy National Institute Of Radiological Sciences
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