Redox Reactions of Tocopherol Monoglucoside inAqueous Solutions: A Pulse Radiolysis Study

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The reactions between tocopherol monoglucoside (TMG), a water-soluble vitamin-E derivative, with Br_2^<・->, N_3^・, (SCN)_2^<・->, NO_2^・, OH^・ and various halogenated peroxyl radicals were examined using a pulse radiolysis technique. The results demonstrate that TMG forms a stable phenoxyl radical at pH > 6.8. The thus-formed phenoxyl radical shows pH-dependent decay kinetics and is disproportionated by 2nd order kinetics at pH 2.3. It was observed that the TMG reactivity towards a halogenated peroxyl radical increases with the number of halogen atoms at the carbon atom having a peroxyl group. The reaction between the TMG phenoxyl radical and ascorbic acid was also examined using a pulse radiolysis technique. The results indicate that the TMG phenoxyl radical is repaired by ascorbate. Kinetic studies indicate that TMG may act as an antioxidant to repair free-radical damage to some biologically important compounds. The one-electron reduction potential for TMG was found to be 0.522 V±0.06 vs. NHE.
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