Potent 2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Activity of Novel Antioxidants, Double-Stranded Tyrosine Residues Conjugating Pyrocatechol
スポンサーリンク
概要
- 論文の詳細を見る
New potent antioxidants conjugating the catechol (=pyrocatechol; pyrCat) group to two N-termini of modified double-stranded tyrosine residues were synthesized and showed radical scavenging activity with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH radical, DPPH˙) as a free radical model, second-order rate constants for the DPPH˙ scavenging reaction, and the results from electron spin resonance (ESR) studies. It was found that the tyrosine (Tyr) residue and pyrCat containing new antioxidants developed in the study have about 3—20 times more potent antioxidative activity than Trolox, pyrCat, and L-ascorbic acid (VC). In order to elucidate the relationship between antioxidant activity and the molecular orbital states, and to design potent antioxidants we present an interesting approach using an absolute hardness (η)–absolute electronegativity (χ) diagram based on chemical hardness. It was shown that quantum chemicals were required to develop potent antioxidants.
- 公益社団法人 日本薬学会の論文
著者
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NAKANISHI Ikuo
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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MATSUMOTO Ken-ichiro
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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ANZAI Kazunori
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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Kobayashi Shigeki
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate S
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Ikuo Nakanishi
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Anzai Kazunori
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Matsumoto Ken-ichiro
Radiation Modifier Res. Team Heavy-ion Radiobiology Res. Group Res. Center For Charged Particle Ther
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Kobayashi Shigeki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Waki Tsukasa
Division of Analytical Chemistry of Medicines, Showa Pharmaceutical University
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Kobayashi Shigeki
Division Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Anzai Kazunori
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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Matsumoto Ken-ichiro
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, U.S.A.
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Nakanishi Ikuo
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
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