Utility Decay Rates of T_1-Weighted Magnetic Resonance Imaging Contrast Based on Redox-Sensitive Paramagnetic Nitroxyl Contrast Agents(Analytical Biochemistry)

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概要

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• The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T_1-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T_1-weighted GE MRI signal intensities according to first-order paramagnetic loss of a nitroxyl contrast agent were simulated for several experimental conditions. The apparent decay rate calculated based on decreasing T_1-weighted MRI contrast (k_<MRI>) can show an approximate value of the original decay rate (k_<true>) discretionarily given for simulation with suitable experimental parameters. The difference between k_<MRI> and k_<true> can be sufficiently small under T_1-weighted spoiled gradient echo (SPGR) scan conditions (repetition time=75ms, echo time=3ms, and flip angle =45°), with a conventional redox-sensitive nitroxyl contrast agent, such as 4-hydroxy-2,2,6,6,-tetramethylpiperidine-N-oxyl (TEMPOL) and/or 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL), and with i.v. doses of below 1.5μmol/g b.w. for mice. The results of this simulation suggest that the k_<MRI> of nitroxyl contrast agents can be the primary index of redox status under biological conditions.

• 公益社団法人日本薬学会の論文
• 2009-04-01

著者

• MATSUMOTO Ken-ichiro

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• Matsumoto Ken-ichiro

  Radiation Modifier Team Heavy-ion Radiobiology Research Group Research Center For Charged Particle T

• Matsumoto Ken-ichiro

  Radiation Modifier Res. Team Heavy-ion Radiobiology Res. Group Res. Center For Charged Particle Ther

• Matsumoto Ken-ichiro

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, U.S.A.

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