Distribution of Hydrogen Peroxide-dependent Reaction in a Gelatin Sample Irradiated by Carbon Ion Beam

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概要

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• We investigated the amount and distribution of hydrogen peroxide (H2O2) generated in a solid gelatin sample irradiated by heavy ion (carbon) beam. We irradiated the gelatin sample, which contained a nitroxyl radical (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, TEMPOL), with a 290-MeV/nucleon carbon beam (~128 Gy). To verify the distribution of H2O2 generation in the irradiated sample, we employed both electron paramagnetic resonance (EPR) spectroscopic and magnetic resonance (MR) imaging methods based on H2O2-dependent paramagnetic loss of TEMPOL. We obtained a distribution profile of the H2O2-dependent reaction in the gelatin sample when we irradiated gelatin samples with carbon beams with several different linear energy transfer (LET) values. Because the profiles of oxygen consumption in the gelatin sample measured by L-band EPR oxymetry and of the H2O2-dependent reaction have almost the same shape, the profile of the H2O2-dependent reaction can be used as an estimation of the profile of the generation of H2O2. The H2O2 profile in one intact gelatin sample scanned by 7-tesla MR imaging showed a similar shape as a result of the EPR experiment. We obtained several hundreds of micromolars of H2O2 generated in a gelatin sample irradiated by carbon beam when 200 Gy was given at the surface of the sample. H2O2 distribution was almost flat, with only a slight peak just before the end of the beam.

• 日本磁気共鳴医学会の論文
• 2010-09-01

著者

• Endo Kazutoyo

  Department Of Physical Chemistry Showa Pharmaceutical University

• Endo Kazutoyo

  昭和薬科大学

• NAKANISHI Ikuo

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• MATSUMOTO Ken-ichiro

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• ANZAI Kazunori

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• NYUI Minako

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• Matsumoto Kenichiro

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Kenichiro

  Department Of Physical Chemistry Showa Pharmaceutical University

• Matsumoto Ken-ichiro

  昭和薬科大学 物理化

• Matsumoto Atsuko

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes

• Ikuo Nakanishi

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Anzai Kazunori

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Ken-ichiro

  Radiation Modifier Res. Team Heavy-ion Radiobiology Res. Group Res. Center For Charged Particle Ther

• Nyui Minako

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• AOKI Ichio

  Magnetic Resonance Molecular Imaging Team, Biophysics Group, Molecular Imaging Center, National Inst

• Aoki Ichio

  Magnetic Resonance Molecular Imaging Team Biophysics Group Molecular Imaging Center National Institu

• Matsumoto Atsuko

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Ken-ichiro

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, U.S.A.

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