Detection of Free Radical Reactions in an Aqueous Sample Induced by Low Linear-Energy-Transfer Irradiation(Analytical Biochemistry)

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概要

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• Quantitative detection of free radical reactions induced by low linear-energy-transfer (LET) irradiation in an aqueous solution was attempted using nitroxyl radicals. The stability and reactivity of reaction mixtures containing a nitroxyl radical and a hydrogen donor, i.e., glutathione (GSH), nicotinamide adenine dinucleotide (NADH), or nicotinamide adenine dinucleotide phosphate (NADPH), were tested. X-band electron paramagnetic resonance (EPR) measurements of several reaction mixtures were performed to find a suitable preparation to quantitatively detect free radical reactions produced by low LET irradiation. The EPR signal intensity of nitroxyl radicals was decreased by low LET irradiation when a hydrogen donor coexisted in the reaction mixture. The combination of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (4-hydroxy-TEMPO, known as TEMPOL) and GSH was most preferable among other preparations tested in this paper, because of the sensitivity and irreversible reaction. The extent of the free radical reaction, i.e., formation of reactive oxygen species, in the reaction mixture depended on the radiation energy when an identical dose was given.

• 社団法人日本薬学会の論文
• 2009-04-01

著者

• Mitchell James

  Radiation Biology Branch, National Cancer Institute, National Institutes of Health

• Endo Kazutoyo

  Department Of Physical Chemistry Showa Pharmaceutical University

• Endo Kazutoyo

  昭和薬科大学

• OKAJO Aya

  Department of Physical Chemistry, Showa Pharmaceutical University

• NAKANISHI Ikuo

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• MATSUMOTO Ken-ichiro

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• ANZAI Kazunori

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• NAGATA Katsura

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• DEGRAFF William

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH

• NYUI Minako

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• UENO Megumi

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• OZAWA Toshihiko

  Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged

• KRISHNA Murali

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH

• YAMAMOTO Haruhiko

  Department of Applied Bioscience, Faculty of Science, Kanagawa University

• Okajo Aya

  Department Of Physical Chemistry Showa Pharmaceutical University

• Matsumoto Kenichiro

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Kenichiro

  Department Of Physical Chemistry Showa Pharmaceutical University

• Okajo Aya

  昭和薬科大学 薬品物理化学研究室

• Okajo Aya

  放射線医学総合研究所重粒子医科学センター

• Okajo Aya

  放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ

• Matsumoto Ken-ichiro

  昭和薬科大学 物理化

• OZAWA Toshihiko

  Department of Health Pharmacy, Yokohama College of Pharmacy

• Krishna Murali

  Radiation Biology Branch Center For Cancer Research National Cancer Institute Nih

• Ikuo Nakanishi

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Anzai Kazunori

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Ken-ichiro

  Radiation Modifier Res. Team Heavy-ion Radiobiology Res. Group Res. Center For Charged Particle Ther

• Ozawa Toshihiko

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Ozawa Toshihiko

  放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ

• Ueno Megumi

  Research Center For Charged Particle Therapy National Institute Of Radiological Sciences

• Nyui Minako

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Mitchell James

  Radiation Biology Branch Center For Cancer Research National Cancer Institute Nih

• Nagata Katsura

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Degraff William

  Radiation Biology Branch Center For Cancer Research National Cancer Institute Nih

• Yamamoto Haruhiko

  Department Of Applied Bioscience Faculty Of Science Kanagawa University

• Matsumoto Ken-ichiro

  Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, U.S.A.

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