Intracellular and Extracellular Redox Environments Surrounding Redox-Sensitive Contrast Agents under Oxidative Atmosphere(Analytical Biochemistry)
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概要
- 論文の詳細を見る
In vivo redox reactions of nitroxyl contrast agents in bile and blood under an oxidative atmosphere were investigated using normal healthy Wistar rats. Differences in intracellular and extracellular volumes in redox environments are discussed. Pharmacokinetic profiles of two nitroxyl contrast agents, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl carbamoyl-PROXYL), 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL), in bile and blood were monitored by an electron paramagnetic resonance spectrometer when the rat was breathing 100% O_2 or was subcutaneously administrated 0.2mmol/kg body weight of ferric citrate. Re-oxidation of hydroxylamines to nitroxyl radicals was caused in bile under 100% O_2 breathing, but not in blood. The administration of ferric citrate caused marked re-oxidation in bile, but a slight reduction in blood. Tissue H_2O_2 level may partly play a role in the intracellular re-oxidation process. Tissue Fe^<3+> concentration can work more effectively for the intracellular re-oxidation of hydroxylamines. The intracellular environment is susceptible to oxidation compared with the extracellular environment under conditions such as 100% O_2 breathing or iron overload.
- 社団法人日本薬学会の論文
- 2009-04-01
著者
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Endo Kazutoyo
Department Of Physical Chemistry Showa Pharmaceutical University
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Endo Kazutoyo
昭和薬科大学
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OKAJO Aya
Department of Physical Chemistry, Showa Pharmaceutical University
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UI Iori
Department of Physical Chemistry, Showa Pharmaceutical University
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MANDA Sushma
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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NAKANISHI Ikuo
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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MATSUMOTO Ken-ichiro
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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ANZAI Kazunori
Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged
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Okajo Aya
Department Of Physical Chemistry Showa Pharmaceutical University
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Ui Iori
Department Of Physical Chemistry Showa Pharmaceutical University
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Ui Iori
昭和薬科大学 薬品物理化学研究室
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Matsumoto Kenichiro
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Matsumoto Kenichiro
Department Of Physical Chemistry Showa Pharmaceutical University
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Okajo Aya
昭和薬科大学 薬品物理化学研究室
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Okajo Aya
放射線医学総合研究所重粒子医科学センター
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Okajo Aya
放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ
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Manda Sushma
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Manda Sushma
Redox Regulation Research Group Research Center For Radiation Safety National Institute Of Radiologi
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Matsumoto Ken-ichiro
昭和薬科大学 物理化
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Ikuo Nakanishi
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Anzai Kazunori
Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P
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Matsumoto Ken-ichiro
Radiation Modifier Res. Team Heavy-ion Radiobiology Res. Group Res. Center For Charged Particle Ther
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Matsumoto Ken-ichiro
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, U.S.A.
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