Feeding Period of Selenium-Deficient Diet and Response of Redox Relating Minerals

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概要

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• Dynamics of redox relating biotrace elements, selenium (Se), iron (Fe), and zinc (Zn) in liver, kidney, and spleen of selenium deficient Wistar male rats in a series of feeding period (from 0 to 8 weeks) were studied using instrumental neutron activation analysis (INAA). Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and blood urea nitrogen (BUN) for the plasma fraction of the rat bloods and the concentration of vitamin C and vitamin E in the liver homogenates were measured. The initial purpose of this study was to find Fe and Zn as sensitive indices of the tissue oxidative stress levels. However, the relationships among the biotrace elements and the oxidative stress/injury were much complicated. Control group, which was fed Se-deficient diet with Na_2SeO_4 (0.1 mg selenium/1) in drinking water, showed strange response of Se and Zn contents in the kidney and showed high BUN. Supplementation of inorganic Se by biased Se source may serve as another source of a stress especially in the kidney. The Fe and Zn contents in the liver and kidney look sensitive to the Se-deficiency and/or relating oxidative stresses. Short term exposure to the Se-deficiency appeared to consume Fe and Zn in the liver and kidney. In contrast, long term or chronic exposure to Se-deficiency appeared to accumulate Fe and Zn in liver and kidney.

• 社団法人日本薬学会の論文
• 2006-12-01

著者

• Endo Kazutoyo

  Department Of Physical Chemistry Showa Pharmaceutical University

• Endo Kazutoyo

  昭和薬科大学

• Satoh Kazue

  Department of Anatomy, School of Medicine,Showa University

• OKAJO Aya

  Department of Physical Chemistry, Showa Pharmaceutical University

• Matsumoto Ken-ichiro

  Department of Physical Chemistry, Showa Pharmaceutical University

• Ariyoshi Marie

  Department of Physical Chemistry, Showa Pharmaceutical University

• Terada Sachiyo

  Department of Physical Chemistry, Showa Pharmaceutical University

• Urata Hiromi

  Department of Physical Chemistry, Showa Pharmaceutical University

• Sakuma Yasunobu

  Department of Physical Chemistry, Showa Pharmaceutical University

• Ushio Fusao

  Office of Quality Assurance, Tokyo Metropolitan Institute of Public Health

• Tsukada Masamichi

  Laboratory of Analytical Chemistry, School of Agriculture, Meiji University

• Okajo Aya

  Department Of Physical Chemistry Showa Pharmaceutical University

• Matsumoto Kenichiro

  Radiation Modifier Research Team Heavy-ion Radiobiology Research Group Research Center For Charged P

• Matsumoto Kenichiro

  Department Of Physical Chemistry Showa Pharmaceutical University

• Okajo Aya

  昭和薬科大学 薬品物理化学研究室

• Okajo Aya

  放射線医学総合研究所重粒子医科学センター

• Okajo Aya

  放射線医学総合研究所重粒子医科学センター 粒子線生物研究グループ

• Sakuma Yasunobu

  Department Of Physical Chemistry Showa Pharmaceutical University

• Matsumoto Ken-ichiro

  昭和薬科大学 物理化

• Matsumoto Ken-ichiro

  Department Of Physical Chemistry Showa Pharmaceutical University

• Satoh Kazue

  Department Of Anatomy School Of Medicine Showa University

• Ushio Fusao

  Office Of Quality Assurance Tokyo Metropolitan Institute Of Public Health

• Urata Hiromi

  Department Of Physical Chemistry Showa Pharmaceutical University

• Terada Sachiyo

  Department Of Physical Chemistry Showa Pharmaceutical University

• Ariyoshi Marie

  Department Of Physical Chemistry Showa Pharmaceutical University

• Satoh Kazue

  Department Of Anatomy School Of Medicine

• Tsukada Masamichi

  Laboratory Of Analytical Chemistry School Of Agriculture Meiji University

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