Effects of Tachykinins and Histamine on the Expression of Thymus-and Activation-Regulated Chemokine mRNA in Peripheral Blood Mononuclear Cells and Human Bronchial Epithelial Cells

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概要

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• We hypothesized that participation of sensory neuropeptides, substance P and neurokinin A in the airway inflammation caused to resistance against the glucocorticoids (GCs) treatment. We have measured the expression level of cytokines and chemokines mRNAs in bronchoalveolar lavage cells (BAL), transbronchial lung biopsies (TBLB) and peripheral blood mononuclear cells (PBMC) by reverse transcriptase polymerase chain reaction (RT-PCR). The mRNAs of interleukin-4 (IL-4) and -5, which are typical Thelper 2 (Th2)-type cytokines, were scarcely detected in all of bronchoalvelar lavage fluid (BALF) and TBLB samples. But the mRNA of Thl-type cytokines, such as IL-12, IL-18, and interferon-γ (IFN-γ), tended to be expressed higher than that of Th2-type cytokines at the early stage of asthma before intervention with GCs. The mRNAs of IL-18, IFN-γ, macrophage-derived chemokine (MDC) and thymus- and activation-regulated chemokine (TARC) tended to be expressed higher than that of nonasthmatic subjects. In vitro study demonstrated that the expression of TARC mRNA induced by the combination of IL-4, IFN-γ, and neurokinin A in human bronchial epithelial cells, BEAS-2B was not inhibited by the treatment of the cells with dexamethasone even at 10^-6M. We proposed that the part of resistance to GCs in the asthmatic patient without GC receptor β expression might be associated with the induction of TARC expression in airway epithelial cells by tachykinines and histamine.

• 公益社団法人日本薬学会の論文
• 2002-12-01

著者

• ADACHI Mitsuru

  Department of Internal Medicine, Showa University School of Medicine

• Kasahara Keita

  昭和大学 薬 医薬情報科学

• Kasahara Keita

  Department Of First Internal Medicine School Of Medicine

• Kasahara Keita

  Department Of First Internal Medicine School Of Medicine Showa University

• Negoro Takaharu

  Department of Phamacogenomics School of Phamaceutical Sciences Showa University

• Nakano Yasuko

  Department of Phamacogenomics School of Phamaceutical Sciences Showa University

• Satoh Kazue

  Department of Anatomy, School of Medicine,Showa University

• Adachi Mitsuru

  Department Of 1^<st> Internal Medicine Showa University

• TOBE Takashi

  Department of Physiological Chemistry, School of Pharmaceutical Sciences Showa University

• IIKURA Yoji

  Department of Pediatrics, Showa University School of Medicine

• OZAWA Tetsuji

  Department of Internal Medicine, Showa University School of Medicine

• Satoh Kazue

  Department Of Medicinal Information School Of Pharmaceutical Sciences

• Takekawa Keiko

  Department of Medicinal Information, School of Pharmaceutical Sciences

• Takekawa Keiko

  Department Of Medicinal Information School Of Pharmaceutical Sciences

• Adachi Mitsuru

  Department Of First Internal Medicine School Of Medicine

• Iikura Yoji

  Department Of Allergy National Children's Hospital

• Iikura Yoji

  Department Of Paediatrics School Of Medicine Showa University

• Tobe T

  Showa Univ. Tokyo Jpn

• Tobe Takashi

  Department Of Biochemistry School Of Medicine Showa University

• Ozawa Tetsuji

  Department Of First Internal Medicine School Of Medicine

• Nakano Yasuko

  Dep. Of Pharmacogenomics School Of Pharmacy Showa Univ.

• Nakano Yasuko

  Department Of Medicinal Information School Of Pharmaceutical Sciences Showa University

• Satoh Kazue

  Department Of Anatomy School Of Medicine

• Negoro Takaharu

  Department Of Biochemistry School Of Medicine Showa University

• Negoro Takaharu

  Department of Medicinal Information, School of Pharmaceutical Sciences

• Nakano Yasuko

  Department of Chemistry, Faculty of Science, Hokkaido University

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