Reduction of GTP Cyclohydrolase I Feedback Regulating Protein Expression by Hydrogen Peroxide in Vascular Endothelial Cells

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概要

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• We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and GTPCH mRNA levels. The inhibitors of nitric oxide (NO) synthase and GTPCH had no influence on the decrease of GFRP mRNA levels in H2O2-treated cells. It is suggested that H2O2 induces BH4 synthesis through not only induction of GTPCH but also reduction of GFRP. The decrease of GFRP mRNA level appears to be independent of the produced NO and BH4.

• 社団法人 日本薬理学会の論文
• 2005-02-20

著者

• ISHII Masakazu

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Negoro Takaharu

  Department of Phamacogenomics School of Phamaceutical Sciences Showa University

• MIYAZAKI Akira

  Department of Biochemistry, Showa University School of Medicine

• Ishii Masakazu

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Ishii Masakazu

  Department Of Pathophysiology School Of Pharmacy Showa University

• Ishii Masakazu

  Center For Integrative Bioscience Okazaki National Research Institutes

• Miyazaki A

  Faculty Of Agriculture Kochi University

• SHIMIZU Shunichi

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• HAGIWARA Tamio

  Department of Biochemistry, Showa University School of Medicine

• WAJIMA Teruaki

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• KIUCHI Yuji

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• TOBE Takashi

  Department of Physiological Chemistry, School of Pharmaceutical Sciences Showa University

• Kiuchi Yuji

  Center Of Pharmaceutical Education School Of Pharmacy Showa Univ.

• Kiuchi Y

  Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn

• Kiuchi Yuji

  Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn

• Tobe Takashi

  Department Of Biochemistry School Of Medicine Showa University

• Wajima Teruaki

  Department Of Pathophysiology School Of Pharmaceutical Sciences Showa University

• Hagiwara Tamio

  Department Of Biochemistry Showa University School Of Medicine

• Miyazaki Akira

  Department Of Biochemistry Kumamoto University School Of Medicine

• Negoro Takaharu

  Department Of Biochemistry School Of Medicine Showa University

• Shimizu Shunichi

  Dep. Of Pathophysiology School Of Pharmacy Showa Univ.

• Miyazaki Akira

  Department Of Biochemistry Faculty Of Medicine Showa University

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