Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats
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概要
- 論文の詳細を見る
The novel antiepileptic drug gabapentin was designed as a structural analog of γ-aminobutyric acid (GABA). However, its mechanism of action remains unclear. In the present study, we investigated the effect of gabapentin on spinal reflexes in anesthetized rats. The mono- and polysynaptic reflex potentials were recorded from the ipsilateral L5 ventral root after stimulation of the L5 dorsal root. The dorsal root reflex potential, an index of presynaptic inhibition, was recorded from the ipsilateral L4 dorsal root. In non-spinalized (intact) and spinalized rats, intravenously administered gabapentin reduced the mono- and polysynaptic reflex potentials in a dose-dependent manner. These inhibitory effects of gabapentin were not suppressed by the GABAA antagonist picrotoxin. Moreover, gabapentin also decreased spinal reflexes in spinalized rats depleted of spinal GABA with semicarbazide, an inhibitor of the GABA-synthesizing enzyme. The dorsal root reflex potentials were not affected by gabapentin. These results suggest that endogenous GABA does not mediate the inhibitory effects of gabapentin on spinal reflexes.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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HONDA Motoko
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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TANABE Mitsuo
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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ONO Hideki
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Oka Jun-ichiro
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Honda Motoko
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Tanabe Mitsuo
名古屋大学 薬学研究科中枢神経機能薬理学
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Tanabe Mitsuo
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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SHIMIZU Shinobu
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Shimizu Shunichi
Dep. Of Pathophysiology School Of Pharmacy Showa Univ.
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences
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Tanabe Mitsuo
Laboratory Of Pharmacology School Of Pharmacy Kitasato University
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