Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 <I>μ</I>mol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission.
- 公益社団法人 日本薬理学会の論文
著者
-
Yamamoto Shohei
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Hisa Hiroaki
Second Department Of Pharmacology School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
-
Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences
-
OHSAWA Masahiro
Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
-
Mutoh Junpei
Second Department Of Pharmacology School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
関連論文
- Relative Contributions of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in 5-HT-Induced Vasoconstriction of the Distended Human Saphenous Vein as a Coronary Artery Bypass Graft
- Taltirelin Improves Motor Ataxia Independently of Monoamine Levels in Rolling Mouse Nagoya, a Model of Spinocerebellar Atrophy(Pharmacology)
- Enhanced Wind-Up of the C-Fiber-Mediated Nociceptive Flexor Reflex Movement Following Painful Diabetic Neuropathy in Mice
- Noxious Stimuli Evoke a Biphasic Flexor Reflex Composed of Aδ-Fiber-Mediated Short-Latency and C-Fiber-Mediated Long-Latency Withdrawal Movements in Mice
- Oseltamivir, an Anti-influenza Virus Drug, Produces Hypothermia in Mice : Comparison Among Oseltamivir, Zanamivir and Diclofenac(Pharmacology)
- Spinorphin, an Endogenous Inhibitor of Enkephalin-Degrading Enzymes, Potentiates Leu-Enkephalin-Induced Anti-allodynic and Antinociceptive Effects in Mice
- Protein Kinase A-Dependence of the Supraspinally Mediated Analgesic Effects of Gabapentin on Thermal and Mechanical Hypersensitivity
- The Supraspinally Mediated Analgesic Effects of Zonisamide in Mice After Peripheral Nerve Injury Are Independent of the Descending Monoaminergic System
- Glycine Transporter Blockade Ameliorates Motor Ataxia in a Mouse Model of Spinocerebellar Atrophy
- Involvement of Supraspinal Imidazoline Receptors and Descending Monoaminergic Pathways in Tizanidine-Induced Inhibition of Rat Spinal Reflexes
- GABA_B Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats
- Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice
- Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats
- Neuroprotection via Strychnine-Sensitive Glycine Receptors During Post-ischemic Recovery of Excitatory Synaptic Transmission in the Hippocampus
- Zonisamide Suppresses Pain Symptoms of Formalin-Induced Inflammatory and Streptozotocin-Induced Diabetic Neuropathy
- Neuroprotection via Strychnine-Sensitive Glycine Receptors During Post-ischemic Recovery of Excitatory Synaptic Transmission in the Hippocampus
- Transgenic potato overexpressing Arabidopsis cytosolic AtDHAR1 showed higher tolerance to herbicide, drought and salt stresses
- Method for Recording Spinal Reflexes in Mice: Effects of Thyrotropin-Releasing Hormone, DOI, Tolperisone and Baclofen on Monosynaptic Spinal Reflex Potentials
- N- and L-Type Voltage-Dependent Ca Channels Contribute to the Generation of After-Discharges in the Spinal Ventral Root After Cessation of Noxious Mechanical Stimulation
- Insulin Induces Internalization of the Plasma Membrane 5-Hydroxytryptamine_ (5-HT_) Receptor in the Isolated Human Endothelium-Denuded Saphenous Vein via the Phosphatidylinositol 3-Kinase Pathway
- N- and L-Type Voltage-Dependent Ca^ Channels Contribute to the Generation of After-Discharges in the Spinal Ventral Root After Cessation of Noxious Mechanical Stimulation
- Greater protection against oxidative damages imposed by various environmental stresses in transgenic potato with higher level of reduced glutathione
- Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
- Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
- 5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases
- Antinociceptive Effects of Sodium Channel-Blocking Agents on Acute Pain in Mice
- Contribution of TRPV1 Receptor-Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model