5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases

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概要

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• 5-Hydroxytryptamine (5-HT) is involved in regulation of both physiological and pathophysiological conditions in tissues throughout the body. 5-HT induces vascular smooth muscle constriction in most vessels. The vasoconstrictive effects of 5-HT are mediated by 5-HT1B and 5-HT2A receptors located on the membrane of smooth muscle cells, except in the intracranial arteries which constrict only through 5-HT1B receptors. 5-HT also acts as vasodilator because it releases nitric oxide from endothelial cells. This response is dominantly mediated by 5-HT1B receptors but not by 5-HT2A receptors. In this review, we focus on the action of 5-HT via G protein-coupled 5-HT receptors involved in some vascular-related pathophysiological responses. Furthermore, we describe the possibilities of 5-HT receptors as targets for drug therapy against saphenous vein grafts diseases (especially in patients with diabetes mellitus), migraine and pulmonary arterial hypertension.

著者

• Yamamoto Ryuichi

  First Dep. Of Pharmacology School Of Pharmaceutical Sciences Kyushu Univ. Of Health And Welfare

• Hisa Hiroaki

  Second Department Of Pharmacology School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare

• Gamoh Shuji

  First Department Of Pharmacology School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare

• Yamamoto Ryuichi

  First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare

• Gamoh Shuji

  First Department of Pharmacology, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare

関連論文

• Relative Contributions of 5-Hydroxytryptamine (5-HT) Receptor Subtypes in 5-HT-Induced Vasoconstriction of the Distended Human Saphenous Vein as a Coronary Artery Bypass Graft
• Inhibitory Effect of Lomerizine, a Prophylactic Drug for Migraines, on Serotonin-Induced Contraction of the Basilar Artery
• Insulin Induces Internalization of the Plasma Membrane 5-Hydroxytryptamine_ (5-HT_) Receptor in the Isolated Human Endothelium-Denuded Saphenous Vein via the Phosphatidylinositol 3-Kinase Pathway
• Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
• Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
• 5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases

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