Inhibitory Effect of Lomerizine, a Prophylactic Drug for Migraines, on Serotonin-Induced Contraction of the Basilar Artery
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概要
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We examined the effects of lomerizine on serotonin (5-hydroxytryptamine, 5-HT)–induced contraction of the basilar artery and compared them with those of nifedipine. Although both lomerizine and nifedipine completely blocked K+-induced vasoconstriction, 5-HT–induced vasoconstriction was more strongly inhibited by lomerizine than nifedipine. A 5-HT2A antagonist inhibited the 5-HT–induced vasoconstriction, but a 5-HT1B antagonist did not. Lomerizine, but not nifedipine, suppressed 5-HT–induced Ca2+ release in 5-HT2A–expressing HEK293 cells. Moreover, neither antagonist affected ATP-induced Ca2+ release. These results suggest that lomerizine may inhibit not only voltage-dependent Ca2+ channels but also 5-HT2A receptors and so inhibit 5-HT–induced contraction in the basilar artery.
- 社団法人 日本薬理学会の論文
- 2009-10-20
著者
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ISHII Masakazu
Department of Cardiology, Nagoya University Graduate School of Medicine
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Yamamoto Ryuichi
First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and
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Ishii Masakazu
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Ishii Masakazu
Department Of Pathophysiology School Of Pharmacy Showa University
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Ishii Masakazu
Center For Integrative Bioscience Okazaki National Research Institutes
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SHIMIZU Shunichi
Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University
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KIUCHI Yuji
Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University
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Kobayashi Shunsuke
Department Of Electronic Engineering (div. Of Engineering Sciences) Faculty Of Technology Tokyo Univ
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Kiuchi Yuji
Center Of Pharmaceutical Education School Of Pharmacy Showa Univ.
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Kiuchi Y
Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn
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Kiuchi Yuji
Department Of Electronic Engineering Faculty Of Technology Tokyo University Of Agriculture And Techn
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Yamamoto Ryuichi
First Dep. Of Pharmacology School Of Pharmaceutical Sciences Kyushu Univ. Of Health And Welfare
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OHKURA Masamichi
Department of Cardiovascular Pharmacology, Yamagata University School of Medicine
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Kobayashi Shunsuke
Department Of Pathophysiology School Of Pharmacy Showa University
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Kobayashi Shunsuke
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Shimizu Shunichi
Dep. Of Pathophysiology School Of Pharmacy Showa Univ.
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Ohkura Masamichi
Department Of Cardiovascular Pharmacology Yamagata University School Of Medicine
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Kobayashi Shunsuke
Department Of Biology Faculty Of Science Yamagata University
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