Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients

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概要

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• We investigated the possible association of serotonin (5-HT) 2A receptor gene A-1438G polymorphism in Japanese patients with migraine. Genotyping of 5-HT2A A-1438G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism in patients with migraine (male 17 : 3 with aura and 14 without aura, female 65 : 17 with aura and 48 without aura) and controls (male 31, female 84). The distribution of 5-HT2A A-1438G genotype frequency between migraine patients and controls did not differ. These results suggest that the A-1438G polymorphism of the 5-HT2A receptor gene is not a direct risk factor for migraine; however, the incidence of the A/A genotype between migraine with aura (MA) and without aura (MO) was significantly different. The 5-HT2A A-1438G polymorphism may be involved in determining the subtypes of migraine in Japanese.

• 公益社団法人　日本薬学会の論文

著者

• ISHII Masakazu

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Shida Kenji

  Department of Cardiology, Kyorin University School of Medicine

• Shida Kenji

  Department Of Cardiology Kawasaki Social Insurance Hospital

• OGUCHI KATSUJI

  Department of Pharmacology, School of Medicine, Showa University

• Masuda Yutaka

  Department of Agricultural Chemistry, The University of Tokyo

• Ishii Masakazu

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Ishii Masakazu

  Department Of Pathophysiology School Of Pharmacy Showa University

• Ishii Masakazu

  Center For Integrative Bioscience Okazaki National Research Institutes

• Oguchi Katsuji

  Department Of Pharmacology School Of Medicine Showa University

• SHIMIZU Shunichi

  Department of Pathophysiology, School of Pharmaceutical Sciences, Showa University

• NAITO YUKO

  Department of Laboratory Medicine, Fukuoka University School of Medicine

• Kiuchi Yuji

  Center Of Pharmaceutical Education School Of Pharmacy Showa Univ.

• HARA HAJIME

  Department of Neurology, Showa University Fujigaoka Hospital

• Hara Hajime

  Department Of Electronics And Photonic Systems Engineering Hiroshima Institute Of Technology

• Naito Yuko

  Department Of Laboratory Medicine Fukuoka University School Of Medicine

• OYAMADA Hideto

  Department of Pharmacology, School of Medicine, Showa University

• IMAGAWA Atsuko

  Department of Internal Medicine, Showa University Fujigaoka Hospital

• Imagawa Atsuko

  Department Of Internal Medicine Showa University Fujigaoka Hospital

• Naito Yuika

  Department of Pathophysiology, School of Pharmacy, Showa University

• Nagamine Ayumu

  Department of Pathophysiology, School of Pharmacy, Showa University

• Takahashi Johji

  Department of Neurology, Showa University Fujigaoka Hospital

• Hosaka Yukiko

  Department of Pathophysiology, School of Pharmacy, Showa University

• Usami Shino

  Department of Pathophysiology, School of Pharmacy, Showa University

• Masuda Yutaka

  Deparmtent Of Cardiovascular Surgery Institute Of Health Biosciences University Of Tokushima Graduat

• Kiuchi Yuji

  Center of Pharmaceutical Education, School of Pharmacy, Showa University

• Naito Yuko

  Department of Pathophysiology, School of Pharmacy, Showa University

• Ishii Masakazu

  Department of Pathophysiology, School of Pharmacy, Showa University

• Imagawa Atsuko

  Department of Neurology, Showa University Fujigaoka Hospital

• Shida Kenji

  Department of Anesthesiology, School of Medicine, Showa University

• Masuda Yutaka

  Department of Anesthesiology, School of Medicine, Showa University

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