STUDIES ON β-PHENYLETHYLAMINE DEAMINATION BY HUMAN PLACENTAL MONOAMINE OXIDASE
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概要
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Kinetical properties of human placental monoamine oxidase (MAO) were investigated in studies on inhibitors and mixed substrates. MAO activity was determined by a radioisotopic assay. Lineweaver-Burk plots were linear at higher and lower concentrations of PEA, whereas at intermediate substrate concentrations, a downward curving plot was obtained. The Km values of the low and high-affinity sites for PEA deamination were estimated. Studies with mixed substrates showed that 5-HT was a competitive inhibitor and tyramine a mixed-type inhibitor of deamination at high concentrations of PEA, whereas both were noncompetitive inhibitors at lower concentrations of PEA. After pre-incubation of human placental mitochondrial preparations with deprenyl, Lineweaver-Burk plots were completely linear, and the Km value was the same as that obtained at low concentrations of PEA in the absence of deprenyl. Tyramine and 5-HT were competitive inhibitors of PEA deamination by deprenyl-treated MAO. From these results it is concluded that there are two kinds of MAO with high- and low-affinity sites for PEA in mitochondria of human placenta, corresponding to type B and A MAO, and that tyramine, 5-HT and PEA share a substrate-binding site on type A MAO, while tyramine and 5-HT bind to a site on type B MAO that is different from the PEA binding site.
- 社団法人 日本薬理学会の論文
著者
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KOBAYASHI Shinichi
Department of Pharmacology, St. Marianna University School of Medicine
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OGUCHI KATSUJI
Department of Pharmacology, School of Medicine, Showa University
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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KAMIJO Kazuya
Department of Pharmacology, School of Medicine, Showa University
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UESATO Tadamasa
Department of Pharmacology, School of Medicine, Showa University
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Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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