Age-Related Changes in Blood Coagulation and Fibrinolysis in Mice Fed on a High-Cholesterol Diet
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the pathogenesis of hyperlipidemia-induced atherosclerosis, we examined age-dependent changes in platelet activity, blood coagulation and fibrinolysis in susceptibility to a high cholesterol diet (HCD) feeding in male ICR mice. Pretreatment of platelet-rich-plasma from HCD feeding mice for 3 days with epinephrine (300 μM) resulted in a marked enhancement of adenosine 5-diphosphate (ADP: 0.1 μM) or collagen (0.7 μg/ml)-stimulated aggregation compared with the same in control mice. Yohimbine as α2-adrenergic blocker antagonized these aggregations in a dose-dependent manner. A significant increase in plasma total cholesterol and VLDL (very low-density lipoprotein)-LDL (low-density lipoprotein)-cholesterol and the liver/body weight ratio was observed in mice fed on HCD for 3 months (3-month HCD mice). In the early phase of this experiment, a significant increase in fibrinogen was observed. In the middle phase, increases in the activity of antithrombin III (ATIII) and α2-plasmin inhibitor (α2-PI) followed. Plasminogen content gradually decreased in both normal diet and HCD mice throughout the experiment. The activity of plasminogen activator inhibitor (PAI) decreased in 3-month HCD mice. Morphological observation of the aortic arch from 3-month HCD mice revealed apparent atheromatous plaques not seen in control mice. These results suggest that 3-month HCD mice can be a convenient hyperlipidemia-induced atherosclerotic model and the changes in platelet activity, coagulation and fibrinolysis in the early phase may be a cause of pathologic changes in this model.
- 社団法人 日本実験動物学会の論文
- 1998-10-01
著者
-
Imai Keiko
Department Of Information And System Engineering Chuo University
-
Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
-
Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa Universtiy
-
Sakamoto Hiromi
Department Of Pharmacology School Of Medicine Showa Universtiy
-
Iwai Shin-ichi
Department Of Pharmacology Showa University School Of Medicine
-
Okazaki M
Department Of Pharmacology Showa University School Of Medicine
-
Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
-
Morio Yuri
Department Of Pharmacology School Of Medicine Showa University
-
Morio Yuri
Department Of Pharmacology School Of Medicine Showa Universtiy
-
MIYAMOTO Kei-ichi
Department of Pharmacology, School of Medicine, Showa Universtiy
-
Miyamoto Kei-ichi
Department Of Pharmacology School Of Medicine Showa Universtiy
-
Imai Keiko
Department Of Pharmacology School Of Medicine Showa Universtiy
-
Okazaki Masao
Department of Pharmacology, School of Medicine, Showa Universtiy
関連論文
- Label Size Maximization for Rectangular Node Labels(Selected Papers from the 18th Workshop on Circuits and Systems in Karuizawa)
- Antidiabetic effects of Kampo medicines in a non-insulin-dependent diabetes mellitus model using KK-Ay mice
- SELECTIVE INHIBITION OF HEPATIC DRUG OXIDIZING ENZYMES BY 480156-S IN MAN
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Effect of a Dihydrobenzofuran Derivative on Lipid Hydroperoxide-Induced Rabbit Corneal Neovascularization
- Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- On the Orthogonal $L_1$ Linear Approximation of Points
- Regulation of dopamine uptake by basic fibroblast growth factor and epidermal growth factor in cultured rat astrocytes
- Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution
- Enhancement of the Coagulation System in Spontaneously Hypertensive and Hyperlipidemic Rats
- Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells
- Novel Mutations in C-terminal Channel Region of the Ryanodine Receptor in Malignant Hyperthermia Patients
- Blood Coagulability and Fibrinolysis in Streptozotocin-induced Diabetic Rats
- STUDIES ON β-PHENYLETHYLAMINE DEAMINATION BY HUMAN PLACENTAL MONOAMINE OXIDASE
- Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
- STUDIES ON HUMAN PLACENTAL MONOAMINE OXIDASE USING MIXED SUBSTRATES
- Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
- Diabetic Nephropathy in KK and KK-A^y Mice
- Age-Related Changes in Blood Coagulation and Fibrinolysis in Mice Fed on a High-Cholesterol Diet
- Graphical Degree Sequence Problems
- Segmental Distraction of the Midface in a Patient With Crouzon Syndrome
- Map Label Placement for Points and Curves
- Computational Investigations of All-Terminal Network Reliability via BDDs (Special Section on Discrete Mathematics and Its Applications)
- HEMODYNAMICS AND MONOAMINE OXIDASE ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
- RELATIONSHIP BETWEEN THIAMINE AND GLUCOSE LEVELS IN DIABETES MELLITUS
- Changes in Coagulative and Fibrinolytic Activities in Triton WR-1339-Induced Hyperlipidemia in Rats
- Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation
- Binding Proteins of Androgen in the Testis of the Rats
- Effect of salts on mitochondrial monoamine oxidase from bovine liver.
- Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese Healthy subjects.
- Pharmacokinetics of cefmetazole in elderly patients and healthy volunteers.
- Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia
- Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine.
- The Response to Acoustic Stimulation and the Changes in Brain Amine Levels after Repeated Administration of .BETA.-Phenylethylamine in Rats.
- Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes.
- Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.
- The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine.
- Changes in brain lipid composition in thiamine deficient rats.
- Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia.
- Mechanisms of the Hypolipidemic Effect of NIP-200 in Rats.
- Function of reticuloendothelial system on CCl4 induced liver injury in mice.
- Studies on alterations in blood coagulative and fibrinolytic activities after single and multiple administrations of carbon tetrachloride in mice.
- Comparative Study of Amine Receptor Stimulated CAMP Formations in the Brain of Spontaneously Hypertensive Rat
- Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
- Properties of monoamine oxidase in monkey heart.
- Function of reticuloendothelial system on ethionine induced liver injury in mice.
- A bioequivalence study of two different crystalline forms of malotilate: A and B.
- Hemodynamics and Monoamine Oxidase Activity in Spontaneously Hypertensive Rat (SHR)
- Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Induced by Cholesterol Free-High Fructose or High Cholesterol Diet.