Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) and L-methionine (L-Met) on rat erythrocytes and primary cultured hepatocytes were studied. SAMe-ST in concentrations of 0.2 to 5.0 mg; ml protected erythrocytes from hypotonic hemolysis. Almost an identical level of protection was provided by SAMe chloride, suggesting that this protective effect is due to the SAMe moiety itself but not its sulfate or tosylate moiety. L-Met also showed a slight protective effect, but at higher concentrations, it slightly enhanced hemolysis. When the cultured hepatocytes were treated with SAMe-ST, the leakage of enzymes from the hepatocytes were significantly decreased compared with that in the control. L-Met also showed similar protective effects, but to a lesser degree than in the case of SAMe-ST. SAMe-ST significantly increased Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase activity. The present results indicate that SAMe remarkably inhibits hypotonic hemolysis and enzyme leakage from cultured hepatocytes and that its mechanism is probably related to a change in the membrane property.
- 公益社団法人 日本薬理学会の論文
著者
-
Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
-
Tsuji Mayumi
Department Of Internal Medicine Osaka Kosei-nenkin Hospital
-
KODAMA Kyoko
Department of Pharmacology, School of Medicine, Showa University
関連論文
- Antidiabetic effects of Kampo medicines in a non-insulin-dependent diabetes mellitus model using KK-Ay mice
- SELECTIVE INHIBITION OF HEPATIC DRUG OXIDIZING ENZYMES BY 480156-S IN MAN
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Effect of a Dihydrobenzofuran Derivative on Lipid Hydroperoxide-Induced Rabbit Corneal Neovascularization
- Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?
- Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- Regulation of dopamine uptake by basic fibroblast growth factor and epidermal growth factor in cultured rat astrocytes
- Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution
- Enhancement of the Coagulation System in Spontaneously Hypertensive and Hyperlipidemic Rats
- Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells
- Novel Mutations in C-terminal Channel Region of the Ryanodine Receptor in Malignant Hyperthermia Patients
- Blood Coagulability and Fibrinolysis in Streptozotocin-induced Diabetic Rats
- STUDIES ON β-PHENYLETHYLAMINE DEAMINATION BY HUMAN PLACENTAL MONOAMINE OXIDASE
- Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
- STUDIES ON HUMAN PLACENTAL MONOAMINE OXIDASE USING MIXED SUBSTRATES
- Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
- Diabetic Nephropathy in KK and KK-A^y Mice
- Age-Related Changes in Blood Coagulation and Fibrinolysis in Mice Fed on a High-Cholesterol Diet
- HEMODYNAMICS AND MONOAMINE OXIDASE ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
- Changes in Coagulative and Fibrinolytic Activities in Triton WR-1339-Induced Hyperlipidemia in Rats
- Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation
- Large Adrenal Ganglioneuroma
- Effect of salts on mitochondrial monoamine oxidase from bovine liver.
- Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese Healthy subjects.
- Pharmacokinetics of cefmetazole in elderly patients and healthy volunteers.
- Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia
- Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine.
- The Response to Acoustic Stimulation and the Changes in Brain Amine Levels after Repeated Administration of .BETA.-Phenylethylamine in Rats.
- Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes.
- Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.
- The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine.
- Changes in brain lipid composition in thiamine deficient rats.
- Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia.
- Mechanisms of the Hypolipidemic Effect of NIP-200 in Rats.
- Comparative Study of Amine Receptor Stimulated CAMP Formations in the Brain of Spontaneously Hypertensive Rat
- Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
- Properties of monoamine oxidase in monkey heart.
- A bioequivalence study of two different crystalline forms of malotilate: A and B.
- Hemodynamics and Monoamine Oxidase Activity in Spontaneously Hypertensive Rat (SHR)
- Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Induced by Cholesterol Free-High Fructose or High Cholesterol Diet.