STUDIES ON HUMAN PLACENTAL MONOAMINE OXIDASE USING MIXED SUBSTRATES

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概要

• 論文の詳細を見る

• The activity of mitochondrial monoamine oxidase (MAO) from human placenta was measured with mixtures of labelled and unlabelled tyramine, serotonin (5-HT), benzylamine and β-phenylethylamine (PEA). Tyramine deamination was inhibited by benzylamine and PEA but not by 5-HT, while benzylamine deamination was inhibited by tyramine and PEA, but not by 5-HT. 5-HT deamination was inhibited by tyramine, benzylamine and PEA and PEA deamination was inhibited by tyramine, benzvlamine and 5-HT. These results suggest that MAO in human placenta has multiple catalytic sites or consists of different enzymes. Probably, tyramine, benzyl-amine and PEA are deaminated oxidatively at a common catalytic site while 5-HT is deaminated at another catalytic site. Benzylamine deamination was inhibited in a mixed noncompetitive fashion by tyramine and PEA in air, but benzylamine deamination was competitively inhibited by PEA at higher concentrations of oxygen. The deaminations of other substrates were inhibited competitively by other substrates, in air. Reciprocal plots of PEA deamination with benzylamine, 5-HT and tyramine gave hyperbolic curves.

• 社団法人 日本薬理学会の論文

著者

• KOBAYASHI Shinichi

  Department of Pharmacology, St. Marianna University School of Medicine

• OGUCHI KATSUJI

  Department of Pharmacology, School of Medicine, Showa University

• Koide Ryohei

  Department of Ophthalmology, Showa University School of Medicine

• Koide Ryohei

  Department Of Ophthalmology School Of Medicine Showa University

• Oguchi Katsuji

  Department Of Pharmacology School Of Medicine Showa University

• Kobayashi Shinichi

  Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo

• KOIDE Ryohei

  Department of Pharmacology, School of Medicine, Showa University

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