Diabetic Nephropathy in KK and KK-A^y Mice
スポンサーリンク
概要
- 論文の詳細を見る
KK mice and KK-Ay mice were examined for age related changes in blood and urinary biophysiological parameters. Blood hemoglobin A1c levels were significantly higher in KK-Ay and KK mice as compared to non-diabetic ddY mice. In both diabetic mice, especially KK-Ay mice, plasma insulin levels markedly increased at 2 to 4 months of age, and the urinary glucose and microalbumin levels and albumin-to-creatinine ratios increased dependent on age. Plasma thrombomodulin levels significantly increased at 2 to 4 months of age in both KK and KK-Ay mice. Mild enlargement of mesengial matrix and segmental proliferative glomerular nephritis were revealed in KK and KK-Ay mice, respectively, at 4 months of age. KK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy.
- 社団法人 日本実験動物学会の論文
著者
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Kikuchi Takuya
Department Of Clinical Veterinary Science Obihiro University Of Agriculture & Veterinary Medicin
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Kikuchi Takuya
Department Of Pharmacology School Of Medicine Showa University
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Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
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Okazaki Masako
Department Of Pharmacology School Of Medicine Showa University
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Saito Yukako
Department Of Pharmacology School Of Medicine Showa University
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UDAKA Yuko
Department of Pharmacology, School of Medicine, Showa University
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MARUYAMA Mine
Department of Pharmacology, School of Medicine, Showa University
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MURAKAMI Hidetomo
Department of Pharmacology, School of Medicine, Showa University
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OTA Sumiko
Department of Pharmacology, School of Medicine, Showa University
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Udaka Yuko
Department Of Pharmacology School Of Medicine Showa University
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Ota Sumiko
Department Of Pharmacology School Of Medicine Showa University
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Maruyama Mine
Department Of Pharmacology School Of Medicine Showa University
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Murakami Hidetomo
Department Of Pharmacology School Of Medicine Showa University
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Murakami Hidetomo
Department Of Neurology Showa University Fujigaoka Hospital
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