Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution
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概要
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We examined oxidative stress and metabolic characteristics of the spontaneously hypertensive hyperlipidemic rat (SHHR) when it was fed a high-fat diet and sucrose solution (HFDS) after NG-nitro-<sc>L</sc>-arginine methyl ester ingestion to develop a rat model of metabolic syndrome. This study was carried out to assess the effects of pioglitazone on levels of lipid peroxide (LPO), Cu,Zn superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), and non-esterified fatty acids (NEFA) in the plasma and liver tissue in HFDS-SHHR compared with Sprague-Dawley rats (SD). In the HFDS-treated groups, levels of LPO, CAT, GPx, and NEFA were elevated and levels of Cu,Zn-SOD were reduced in the plasma and liver tissue, with a marked accumulation of visceral fat. The changes induced by HFDS feeding were severe in the SHHR model that had essential hypertension and hyperlipidemia, when compared with SD that did not have these essential risk factors. Subcutaneous injection of 10 mg/kg/day of pioglitazone for 2 months significantly restored levels of LPO, CAT, GPx, Cu,Zn-SOD, and NEFA in the HFDS-SHHR group, and visceral fat accumulation was reduced. These results suggest that HFDS-SHHR is a suitable model of metabolic syndrome and that pioglitazone treatment can improve oxidative dysregulation in this rat model.
- 社団法人 日本薬理学会の論文
- 2007-10-20
著者
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KUMAI Toshio
Department of Pharmacology, St. Marianna University School of Medicine
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KOBAYASHI Shinichi
Department of Pharmacology, St. Marianna University School of Medicine
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OGUCHI KATSUJI
Department of Pharmacology, School of Medicine, Showa University
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IWAI Shinichi
Department of Pharmacology, School of Medicine, Showa University
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Oguchi Katsuji
Dep. Of Pharmacology School Of Medicine Showa Univ. Jpn
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Oguchi K
Showa Univ. Tokyo Jpn
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Oguchi Katsuji
Department Of Pharmacology Showa University School Of Medicine
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Kobayashi Shinichi
Department Of Pharmacology School Of Medicine Showa University:shionogi Research Laboratories Shiono
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Kumai T
Dep. Of Pharmacogenomics St. Marianna Univ. School Of Medicine
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Kumai Toshio
Department Of Pharmacology St Marianna University School Of Medicine
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Iwai Shinichi
Department Of Pharmacology School Of Medicine Showa University
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Iwai Shin-ichi
Department Of Pharmacology Showa University School Of Medicine
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SAIKI Ryo
Department of Pharmacology, Showa University School of Medicine
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OKAZAKI Masako
Department of Pharmacology, Showa University School of Medicine
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Okazaki M
Department Of Pharmacology Showa University School Of Medicine
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Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
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Saiki Ryo
Department Of Pharmacology Showa University School Of Medicine
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Kobayashi Shinichi
Department Of Pharmacology St. Marianna University School Of Medicine
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Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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OGUCHI Katsuji
Department of Pharmacology, Showa University School of Medicine
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Kumai Toshio
Department of Pharmacogenomics, St. Marianna University School of Medicine
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