Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
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概要
- 論文の詳細を見る
The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-<sc>L</sc>-arginine-methyl ester (<sc>L</sc>-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with <sc>L</sc>-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the α- and β-chains of fibrinogen, whereas plasma NO2− level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that <sc>L</sc>-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase.
- 社団法人 日本薬理学会の論文
- 2005-05-20
著者
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OGUCHI KATSUJI
Department of Pharmacology, School of Medicine, Showa University
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Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
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Oguchi Katsuji
Department Of Pharmacology Showa University School Of Medicine
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OKAZAKI Masako
Department of Pharmacology, Showa University School of Medicine
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TAKINISHI Yasutaka
Department of Pharmacology, Showa University School of Medicine
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Okazaki Masako
Department Of Pharmacology Showa University School Of Medicine
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Okazaki Masako
Department Of Orthodontics School Of Dentistry University Of Tokushima
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Takinishi Yasutaka
Department Of Pharmacology Showa University School Of Medicine
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