Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese Healthy subjects.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of ranitidine, metoclopromide, and anisotropine methylbromide on the absorption of cefpodoxime proxetil (CS-807) were examined in two studies. Pharmacokinetic parameters of R-3763, an active metabolite of CS-807 by non-specific esterases in the intestinal wall, were calculated and compared.<BR>1) A single dose of ranitidine (150 mg) was administered orally to six healthy male subjects 1. 5 hr before the dose of CS-807 (100 mg). Intragastric pH was monitored through a micro-pH-electrode for 6.5 hr after ranitidine treatment (two-way crossover).<BR>2) Nine healthy volunteers were studied for the effect of metoclopromide (MCP) and anisotropine methylbromide (ATMB) (three-way crossover).<BR>Ranitidine treatment resulted in a significant decrease in the parameters: k<SUB>a</SUB> (from 0.957±0.052<I>l</I>/hr to 0.612±0.030<I>l</I>/hr; P<0.05); C<SUB>max</SUB> (from 1.44±0.05μg/ml to 0.67±0.04μg/ml; P<0.01); AUC (from 7.33±0.40μghr/ml to 4.10±0.13μg hr/ ml; P<0.01); the amount of urinary excretion (37.75±0.72% to 21.07±1.82%: P< 0. 01). This indicates that the absorption of CS-807 is affected probably by the increased gastric pH and by the decrease of the dissolution of CS-807 in the stomach.<BR>In contrast to the effect of ranitidine, no significant difference was found for the pharmacokinetic parameters of R-3763 among the groups of MCP, ATMB, and the control, except for the amount excreted into the urine between MCP (31.32±1.84%) and ATMB groups (39.80±3.18%) (P<0.05).<BR>From these results, a sufficient low gastric pH and delayed gastric emptying time should be required for better absorption of CS-807 in man.
- 一般社団法人 日本臨床薬理学会の論文
著者
-
Oguchi Katsuji
Department Of Pharmacology School Of Medicine Showa University
-
KAI KENICHI
Department of Biotechnology, Faculty of Engineering, Nagoya University
-
Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
-
Uchida Eiji
Department Of Cardiology Seirei Yokohama General Hospital
-
Hisaoka Masafumi
Product Development Laboratories Sankyo Company Ltd.
-
Yasuhara Hajime
Department Of Neonatal Intensive Care Unit Nara Prefectural Hospital
-
HISAOKA Masafumi
Product Development Labs. I, Sankyo Co., Ltd.
-
KAI Kenichi
Department of Pharmacology, School of Medicine, Showa University
関連論文
- Irinotecan Activates p53 With Its Active Metabolite, Resulting in Human Hepatocellular Carcinoma Apoptosis
- Antidiabetic effects of Kampo medicines in a non-insulin-dependent diabetes mellitus model using KK-Ay mice
- Effects of a Calcium-Channel Blocker (CV159) on Hepatic Ischemia/Reperfusion Injury in Rats: Evaluation with Selective NO/pO2 Electrodes and an Electron Paramagnetic Resonance Spin-Trapping Method
- WII-06 The eligibility of the non-clinical toxicological studies for the first trial on human (for human screening study) : 4. From the viewr point of IRB
- PE-222 The Decrease of Plaque Volume during PCI Has Negative Impact on Coronary Flow in Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 12 (IHD) : PE38)(Poster Session (English))
- Slow-Flow Phenomenon during Percutaneous Coronary Intervention in Acute Myocardial Infarction : An Intravascular Ultrasound Study
- The Influences of Hemodialysis and AV-Shunt on Bilateral Internal Thoracic Artery Flows : An Ultrasound Study
- OJ-060 Many patients' backgrounds and cardiac conditions except for ejection fraction will not worsen the defibrillation threchold in long term follow-up.(Arrhythmia, therapy(06)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Jap
- SELECTIVE INHIBITION OF HEPATIC DRUG OXIDIZING ENZYMES BY 480156-S IN MAN
- TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Individual Metabolic Capacity Evaluation of Cytochrome P450 2C19 by Protein and Activity in the Small Intestinal Mucosa of Japanese Pancreatoduodenectomy Patients
- Effect of a Dihydrobenzofuran Derivative on Lipid Hydroperoxide-Induced Rabbit Corneal Neovascularization
- FRS-148 Significance of Small Notch Potentials in the Late Phase of T-waves Induced by Na channel Blockade in Brugada Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
- Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine
- Electrophysiological Characteristics in Brugada Syndrome-Like ST Elevation Induced by Pilsicainide Administration
- Predictability of the Na Channel Blockade Induced Brugada Syndrome-Like Electrocardiogram Using Genotype Screening in the SCN5A Gene
- Relationship between the ECG and SCN5A Gene Mutation in Brugada Syndrome
- Follow-up survey of a large-scale multicenter, double-blind study of triple therapy with lansoprazole, amoxicillin, and clarithromycin for eradication of Helicobacter pylori in Japanese peptic ulcer patients
- Efficacy of Levocabastine Hydrochloride Ophthalmic Suspension in the Conjunctival Allergen Challenge Test in Japanese Subjects with Seasonal Allergic Conjunctivitis
- Antenatal Glucocorticoid Therapy Accelerates ATP Production With Creatine Kinase Increase in the Growth-Enhanced Fetal Rat Heart
- Expression of CYP3A4 mRNA Is Correlated With CYP3A4 Protein Level and Metabolic Activity in Human Liver
- Effects of Sodium Nitroprusside on the Catecholamine Synthetic Pathway in the Adrenal Medulla of Rats
- Effects of Ovariectomy and Estrogen Replacement on Aota Angiotensin-Converting Enzyme Activity in Rats
- Changes of Hepatic Microsomal Oxidative Drug Metabolizing Enzymes in Chronic Renal Failure (CRF) Rats by Partial Nephrectomy
- Lead Extractions are not Necessarily Required in the Treatment of Cases with Local Complications Unproven Resional/systemic Infection at the Pacemaker/implantable Cardioverter Defibrillator (ICD) Site
- Driving and Social Relationships of ICD Implanted Patients
- The prospect of a small-sized vibrating flow pump for an artificial heart
- PJ-625 Identification and Expression of Troponin T by Antenatal Glucocorticoid Therapy in Fetal and Infant Rats Using a Proteomic Analysis(Cardiac function, basic/clinical(04)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- Irinotecan-Induced Apoptosis Is Inhibited by Increased P-Glycoprotein Expression and Decreased p53 in Human Hepatocellular Carcinoma Cells(Molecular and Cell Biology)
- The Elucidation of the Mechanism of Weight Gain and Glucose Tolerance Abnormalities Induced by Chlorpromazine
- Utilization of Human Liver Microsomes to Explain Individual Differences in Paclitaxel Metabolism by CYP2C8 and CYP3A4
- Experimental Study on the Effectiveness and Safety of Radiofrequency Catheter Ablation With the Cooled Ablation System
- Multicentric pancreatic intraepithelial neoplasias (PanINs) presenting with the clinical features of chronic pancreatitis
- Changes to levels of serum neuron-specific enolase in a patient with small cell carcinoma of the pancreas
- Clinical outcome of laparoscopic distal pancreatectomy
- Effects of Antenatal Dexamethasone on Antioxidant Enzymes and Nitric Oxide Synthase in the Rat Lung
- Autonomic Imbalance as a Property of Symptomatic Brugada Syndrome
- Antenatal Glucocorticoid Therapy Accelerates ATP Production With Creatine Kinase Increase in the Growth-Enhanced Fetal Rat Heart
- Solid and cystic tumor of the pancreas in a 12-year-old boy
- Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes
- Transferring Images via the Wireless Messaging Network Using Camera Phones Shortens the Time Required to Diagnose Acute Coronary Syndrome
- ANALYSES OF ACTIVE SUBSTANCES DYNAMICS IN THE CENTRAL NORADRENERGIC, DOPAMINERGIC, SEROTONERGIC, CHOLINERGIC AND AMINO ACIDERGIC NERVOUS SYSTEMS BY HPLC-MULTIPLE COULOMETRIC ECD
- Analysis of Desorbed Gases from an Insulator Excited by Electron Impact
- Clinical Use of D-Dimer Measurement for the Diagnosis of Disseminated Intravascular Coagulation in Dogs
- Insecticide Production by Recombinant Bacillus subtilis 1A96 in Fed-Batch Culture with Control of Glucose Concentration
- High Concentration Culture of Bacillus subtilis spo^- Mutant Strain Carrying a Recombinant Plasmid
- Effects of oscillation on the arteries measured by arterial impedance during left ventricular assistance
- Regulation of dopamine uptake by basic fibroblast growth factor and epidermal growth factor in cultured rat astrocytes
- N-Methyl-D-aspartate Induces Phosphorylation of cAMP Response Element (CRE)-Binding Protein and Increases DNA-Binding Activity of CRE in Rat Retina
- Isolation of Cytopathic Small Round Virus (Aichi Virus) from Pakistani Children and Japanese Travelers from Southeast Asia
- Hypertension Accelerates Diabetic Nephropathy in Wistar Fatty Rats, a Model of Type 2 Diabetes Mellitus, via Mitogen-Activated Protein Kinase Cascades and Transforming Growth
- Effects of Pioglitazone on Increases in Visceral Fat Accumulation and Oxidative Stress in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-Fat Diet and Sucrose Solution
- Enhancement of the Coagulation System in Spontaneously Hypertensive and Hyperlipidemic Rats
- Inhibitory Effects of Sasa senanensis Rehder Extract (SE) on Calcium-Ionophore A23187 : Induced Histamine Release From Rat Peritoneal Exudate Cells
- Novel Mutations in C-terminal Channel Region of the Ryanodine Receptor in Malignant Hyperthermia Patients
- STUDIES ON β-PHENYLETHYLAMINE DEAMINATION BY HUMAN PLACENTAL MONOAMINE OXIDASE
- Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
- STUDIES ON HUMAN PLACENTAL MONOAMINE OXIDASE USING MIXED SUBSTRATES
- Involvement of Tyrosine Hydroxylase Upregulation in Cyclosporine-Induced Hypertension
- Potential of Lansoprazole as a Novel Probe for Cytochrome P450 3A Activity by Measuring Lansoprazole Sulfone in Human Liver Microsomes
- Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
- Laparoscopic pancreatic resection : some benefits of evolving surgical techniques
- Comparison of the Effects of Omeprazole and Rabeprazole on Ticlopidine Metabolism In Vitro
- Effects of Castration and Testosterone Administration on Angiotensin II Receptor mRNA Expression and Apoptosis-related Proteins in Rat Urinary Bladder
- Diabetic Nephropathy in KK and KK-A^y Mice
- Age-Related Changes in Blood Coagulation and Fibrinolysis in Mice Fed on a High-Cholesterol Diet
- Pyogenic Liver Abscess Caused by Direct Invasion of Esophageal Squamous Cell Carcinoma to the Liver : Report of a Case
- Comparison of the Effects of Omeprazole and Rabeprazole on Ticlopidine Metabolism In Vitro
- Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes
- HEMODYNAMICS AND MONOAMINE OXIDASE ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)
- How to Develop the New Drugs in Clinical Trials(PUBLIC NIGHT SEMINAR : HOW THE SAFETY OF MEDICINES IS INSURED)
- Changes in Coagulative and Fibrinolytic Activities in Triton WR-1339-Induced Hyperlipidemia in Rats
- Evaluation of the efficacy and safety of intravenous ciprofloxacin versus meropenem in the treatment of postoperative infection
- Dependence of Prebreakdown Currents in Vacuum on Anode Oxidation Conditions
- Tea Polyphenols Inhibit Rat Osteoclast Formation and Differentiation
- Effect of salts on mitochondrial monoamine oxidase from bovine liver.
- Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese Healthy subjects.
- Pharmacokinetics of cefmetazole in elderly patients and healthy volunteers.
- Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia
- Localization of mRNA level and Activity of Tyrosine Hydroxylase in Spontaneously Hypertensive Rats
- Effect of caerulein with haloperidol on monoamine contents in rat brain regions treated with methamphetamine.
- The Response to Acoustic Stimulation and the Changes in Brain Amine Levels after Repeated Administration of .BETA.-Phenylethylamine in Rats.
- Protective effect of S-adenosyl-L-methionine against CCl4-induced hepatotoxicity in cultured hepatocytes.
- Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.
- The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine.
- Changes in brain lipid composition in thiamine deficient rats.
- Sustained Increase in Adrenergic Activity in Gerbil Striatum Following Transient Ischemia.
- Drug Interaction Between Mosapride and Erythromycin Without Electrocardiographic Changes.
- Mechanisms of the Hypolipidemic Effect of NIP-200 in Rats.
- Comparative Study of Amine Receptor Stimulated CAMP Formations in the Brain of Spontaneously Hypertensive Rat
- Antipyrine metabolism in female Lewis and Dark Agouti strains of rats, which are extensive and poor metabolizers of debrisoquine, respectively.
- Elevated Tyrosine Hydroxylase mRNA Levels in the Adrenal Medulla of Spontaneously Hypertensive Rats.
- The Facilitative Effects of Testosterone on the Expression of Tyrosine Hydroxylase mRNA in Adrenal Medulla of Spontaneously Hypertensive Rats. In Vivo and In Vitro Studies
- Properties of monoamine oxidase in monkey heart.
- Possible Involvement of Androgen in Increased Norepinephrine Synthesis in Blood Vessels of Spontaneously Hypertensive Rats.
- A bioequivalence study of two different crystalline forms of malotilate: A and B.
- Hemodynamics and Monoamine Oxidase Activity in Spontaneously Hypertensive Rat (SHR)
- Correlation between Plasma Fibrinogen and Serum Lipids in Rats with Hyperlipidemia Induced by Cholesterol Free-High Fructose or High Cholesterol Diet.