Elevated Tyrosine Hydroxylase mRNA Levels in the Adrenal Medulla of Spontaneously Hypertensive Rats.
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概要
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We investigated the expression of tyrosine hydroxylase (TH) mRNA and its activity in the adrenal medulla of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The TH mRNA levels were determined by Northern blot and dot blot analyses. The TH activity and the expression of TH mRNA in the adrenal medulla of SHR were significantly higher than those of WKY (P <0.01). These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.
- 公益社団法人 日本薬理学会の論文
著者
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Tanaka Masami
Department Of Applied Chemistry College Of Engineering University Of Osaka Prefecture
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Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Kumai Toshio
Department of Pharmacogenomics, St. Marianna University School of Medicine
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