Effects of Sodium Nitroprusside on the Catecholamine Synthetic Pathway in the Adrenal Medulla of Rats
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概要
- 論文の詳細を見る
We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP+nicotine (Nic)-treated group were increased significantly compared to those in the control, Nic-treated and SNP-treated groups. Furthermore, methylene blue inhibited this increase in TH activity. The data suggest that the NO derived from SNP may increase TH through the guanylyl cyclase pathway in the presence of Nic.
- 社団法人 日本薬理学会の論文
- 1998-07-01
著者
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KUMAI Toshio
Department of Pharmacology, St. Marianna University School of Medicine
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KOBAYASHI Shinichi
Department of Pharmacology, St. Marianna University School of Medicine
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Kobayashi Shinichi
聖マリアンナ医科大学 小児科学教室
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TANAKA Masami
Department of Internal Medicine, Misato Kenwa Hospital
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Tanaka M
Dep. Of Pathology St. Marianna Univ. School Of Medicine
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TATEISHI Tomonori
Department of Pharmacology, St. Marianna University Schoot of Medicine
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ASOH Masako
Department of Pharmacology, St. Marianna University Schoot of Medicine
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Takagi Masayuki
Dep. Of Pathology St. Marianna Univ. School Of Medicine
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Kobayashi Shinichi
Dep. Of Pharmacology St. Marianna Univ. School Of Medicine
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Kobayashi Shinichi
Department Of Pharmacology School Of Medicine Showa University:shionogi Research Laboratories Shiono
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Asoh Masako
Department Of Pharmacology St. Marianna University Schoot Of Medicine
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Kumai T
Dep. Of Pharmacogenomics St. Marianna Univ. School Of Medicine
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Kumai Toshio
Department Of Pharmacology St Marianna University School Of Medicine
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Tateishi Tomonori
Department Of Clinical Pharmacology Hirosaki University School Of Medicine
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Tateishi Tomonori
Department Of Cardiology Jichi Medical School
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Tanaka Masami
Tanaka Laboratory of Advanced Technology
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Takagi Masayuki
Department Of Pathology St Marianna University School Of Medicine
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Tanaka Masami
Department Of Applied Chemistry College Of Engineering University Of Osaka Prefecture
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Kobayashi Shinichi
Department Of Biomedical Engineering Graduate School Of Medicine University Of Tokyo
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Kumai Toshio
Department of Pharmacogenomics, St. Marianna University School of Medicine
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