DISTURBANCE OR RELATIVELY IMPORTANT ACTIONS OF ANTIHYPERTENSIVES, ANTIFUNGAL AGENT AND OPIATE ANTAGONIST TO THE TESTICULAR STEROIDOGENESIS IN RAT
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概要
- 論文の詳細を見る
Some of antihypertensives, opiate antagonist and antifungal agent can interfere with sexual function in both men and women. Drug-related effects on sexual function may be difficult to distinguish from the direct action of gonadal function. Clinically well known those agents to have sexual dysfunction were selected and examined the direct effect on rat's testicular steroidogenesis in vitro. Donryu rats were decapitated at 11 weeks old and isolated testes were decapsulated and preincubated with Krebs-Ringer-phosphate buffer (KRP) added with 1μg/flask of LH for 60 min at 37℃. Then, incubation was made with prazosin (1μg), clonidine (5μg), verapamil (10μg), naloxone (5μg) and ketoconazole (150μg), 37℃ for 180 min in fresh KRP-buffer, respectively. Steroids were analysed with RIA, and microfluorometry after purification with quantitative thin layer chromatography. Prazosin had a tendency to produce dihydrotestosterone (DHT) indicating a facilitation of 5α-reductase, and clonidine showed a significant production of estradiol (E_2) with a slight production of DHT indicating a significant facilitation of aromatase. Verapamil had a action to produce significantly E_2 with a slight production of DHT, and naloxone showed a significant production of both DHT and E_2. Thus, these two agents showed facilitation of both 5α-reductase and aromatase. Ketoconazole had a significant production of both Δ4-androstenedione (Δ4-A) and E_2 while it had a significant inhibition of DHT-production, thus this had a significant production of both aromatase and C_<17,20>-lyase while had a significant inhibitory action of 5α-reductase. These findings indicates that comparatively large doses of central-nervous system depressants are one of the factors that interfere with sexual function, but it is not necessary to have direct action to testicular function, however present study revealed that some of them can cause gonadal damage and consecuently progressive loss of libido.
- 日本トキシコロジー学会の論文
- 1992-05-25
著者
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KUMAI Toshio
Department of Pharmacology, St. Marianna University School of Medicine
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MASUBUCHI Yoshiko
Department of Earth Sciences, University of Toyama
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TANAKA Masami
Department of Internal Medicine, Misato Kenwa Hospital
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Tanaka M
Dep. Of Pathology St. Marianna Univ. School Of Medicine
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WATANABE Minoru
Department of Pharmacology, St. Marianna University School of Medicine
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Manabe Hiroko
Shin Nippon Biomedical Laboratories Ltd.
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Takagi Masayuki
Dep. Of Pathology St. Marianna Univ. School Of Medicine
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Kumai T
Dep. Of Pharmacogenomics St. Marianna Univ. School Of Medicine
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Kumai Toshio
Department Of Pharmacology St Marianna University School Of Medicine
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Watanabe Minoru
Dep. Of Pharmacology St. Marianna Univ. School Of Medicine
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Hirai Masanao
Shin Nippon Biomedical Laboratories Ltd.
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Hirai Masanao
Department of Pharmacology, St. Marianna University School of Medicine
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AKAIKE Mari
Department of Pharmacology, St. Marianna University School of Medicine
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Tanaka Masami
Tanaka Laboratory of Advanced Technology
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HIRAI Masanao
Division of Biomedical Science, Shin Nippon Biomedical Laboratories
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Masubuchi Yoshiko
Division Of Biomedical Science Shin Nippon Biomedical Laboratories
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Masubuchi Yoshiko
Department Of Pharmacology St. Marianna University School Of Medicine
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Masubuchi Yoshiko
Department Of Earth Sciences University Of Toyama
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Takagi Masayuki
Department Of Pathology St Marianna University School Of Medicine
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Akaike Mari
Department Of Pharmacology St. Marianna University School Of Medicine
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Hirai Masanao
Clinical Pharmacology Shin Nippon Biomedical Laboratories Ltd.
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Hirai Masanao
Department Of Pharmacology St. Marianna University School Of Medicine
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Masubuti Yoshiko
Shin Nippon Biomedical Laboratories Ltd.
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Tanaka Masami
Department Of Applied Chemistry College Of Engineering University Of Osaka Prefecture
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Kumai Toshio
Department of Pharmacogenomics, St. Marianna University School of Medicine
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