MOTOR DYSFUNCTION IN SPONTANEOUS THYMOMA RATS, BUFFALO/MNA
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概要
- 論文の詳細を見る
The muscle responsiveness of rats of Buffalo/Mna strain with spontaneous thymoma (Mna rats) was investigated in vivo electrophysiologically and pharmacologically in order to determine the principal cause of the muscle weakness and fatigability. Hindlimb muscles of these rats exhibited a lesser contractility and a greater fatigability during repecitive nerve stimulation than those of rats of another strain, ACI. Nevertheless, there was no difference in the time course of amplitude of evoked electromyograms between Mna and ACI rats. According to the test of drug sensitivity, Mna rats were much less sensitive to curare than ACI rats. Sensitivity to 4-aminopyridine was normal. In conclusion, Mna rats showed an increased fatigability and weakness of the muscle. The principal cause seems to be involved in contractile mechanisms subsequent to muscle cell membrane. The reduced sensitivity to curare suggests a possibility of change some at the site of neuro-muscular junction.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Minoru
Department of Pharmacology, St. Marianna University School of Medicine
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Kato Fuminori
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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