Opening of Ca^<2+>-Dependent K^+Channels by Nordihydroguaiaretic Acid in Porcine Coronary Arterial Smooth Muscle Cells
スポンサーリンク
概要
- 論文の詳細を見る
Effects of nordihydroguaiaretic acid (NDGA) on the Ca<SUP>2+</SUP>-dependent K<SUP>+</SUP> channel (BK channel) were examined by the patch clamp technique in single smooth muscle cells of porcine coronary artery. The open probability of BK channels in inside-out patches increased by about 30 times at the holding potential of 0 mV, when 10μM NDGA was added to the bathing solution (pCa 7.0). The effect of NDGA was concentration-dependent in the range of 1—100μM and partly removed by washout. The enhancement of BK channels by NDGA was not observed when the cytosolic Ca<SUP>2+</SUP> concentration was very low (pCa > 8.5). These results clearly indicate that NDGA possesses a BK channel opening property in coronary arterial myocytes.
- 社団法人 日本薬理学会の論文
- 1996-03-01
著者
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Hirano Masaru
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Hirano M
Nagoya Univ. Nagoya Jpn
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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NAGANO Norihiro
Department of Chemical Pharmacolgy, Faculty of Pharmaceutical Sciences, Nagoya City University
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Nagano Norihiro
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe M
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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