Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Action Potential in Guinea Pig Atrium
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概要
- 論文の詳細を見る
Electrophysiological effects of sematilide, a novel class III antiarrhythmic agent, were examined and compared with those of (±)sotalol in guinea pig left atrium by a conventional microelectrode technique. Application of 0.1-1000 μM sematilide or 1-1000 μM (±)sotalol concentration-dependently prolonged the duration of action potentials (APD) that were elicited by electrical stimulation at 1 Hz. Other parameters of action potentials such as the maximum upstroke velocity of phase 0 depolarization, action potential amplitude and resting membrane potential were not affected significantly by these drugs in the concentration ranges employed. The prolongation of APD by sematilide or (±)sotalol was accompanied by a corresponding increase in the effective refractory period (ERP). Approximately a 30% increase in ERP was obtained by the treatment with 5 μM sematilide or 100 μM (± )sotalol, suggesting that sematilide as a class III antiarrhythmic agent is approximately 20 times more potent than (±)sotalol on a molecular basis. When the stimulation rate was increased stepwise from 0.2 to 2 Hz, the relative increase in APD at 90% repolarization by the treatment with sematilide and (±)sotalol was slightly larger at 2 Hz than at 0.2 Hz, indicating that “reverse rate-dependence” was not observed under these conditions. These results may suggest a possibility that sematilide effectively blocks atrial arrhythmia.
- 社団法人 日本薬理学会の論文
- 1995-06-01
著者
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村木 克彦
名古屋市大・院・細胞分子薬効解析
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Kurihara Atsushi
Biology Section Shirakawa Laboratory Nippon Roussel Co. Ltd.
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Muraki Katsuhiko
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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ISHII Yasunori
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe M
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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