Malignancy Grade-Dependent Expression of K+-Channel Subtypes in Human Prostate Cancer
スポンサーリンク
概要
- 論文の詳細を見る
K+ channels are key molecules in the progression of several cancer types and considered to be potential targets for cancer therapy. We examined the gene expressions of voltage-gated (Kv), Ca2+-activated (KCa), and two-pore domain (K2P) K+-channel subtypes in needle-biopsy samples of human prostate cancer (PCa) by real-time PCR and compared them with those in PCa epithelial cell lines. The expression of Kv1.3, KCa1.1, KCa3.1, and K2P1 markedly increased in the PCa group with Gleason score of 5 – 6 (GS5–6) but significantly decreased in the GS8–9 group. This malignancy grade–dependent K+-channel expression pattern may provide a convenient marker to understand PCa progression level.
著者
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Kojima Yoshiyuki
Department of Materials and Applied Chemistry, Faculty of Science and Engineering, Nihon University
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Sasaki Shoichi
Department Of Nephro-urology Nagoya City University Graduate School Of Medical Sciences
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Kohri Kenjiro
Department Of Nephro-urology Nagoya City University Graduate School Of Medical Science
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Ohno Akitoshi
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Kimura Kazunori
Educational Research Center Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Nagoya C
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Niwa Satomi
Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Kimura Kazunori
Educational Research Center of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Imaizumi Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Kohri Kenjiro
Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Japan
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Sasaki Shoichi
Department of Nephro-urology, Graduate School of Medical Sciences, Nagoya City University, Japan
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Niwa Satomi
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Ohno Akitoshi
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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