SK4 Encodes Intermediate Conductance Ca^<2+>-Activated K^+ Channels in Mouse Urinary Bladder Smooth Muscle Cells
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概要
- 論文の詳細を見る
The single channel current of intermediate conductance Ca2+−activated K+ channel(IK channel)was measured in mouse urinary bladder myocytes(MBM), and the molecular basis of the channel was suggested to be the SK4 subtype by RT−PCR.Among Ca2+−activated K+ channel subtypes(SK2, SK3, SK4 and BK), the mRNAs of SK4 and BK were predominantly expressed in MBM.IK channel currents recorded from MBM showed:38.7 pS slope conductance under symmetrical 140 mM K+ conditions, Ca2+−dependent activation, and blockade by charybdotoxin and econazole.These results strongly suggest that SK4 encodes IK channels in MBM.
- 社団法人 日本薬理学会の論文
- 2000-09-01
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Kimura Shingo
Department Of Physiology School Of Medicine Iwate Medical University
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KIMURA Shunichi
Department of Cardiovascular Surgery, Nihon University School of medicine
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村木 克彦
名古屋市大・院・細胞分子薬効解析
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MURAKI Katsuhiko
Department of Molecular and Cellular Phamacology, Graduate School of Pharmaceutical Sciences, Nagoya
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WATANABE Minoru
Department of Pharmacology, St. Marianna University School of Medicine
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Muraki Katsuhiko
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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Kimura S
Department Of Physiology School Of Medicine Iwate Medical University
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KITSUKAWA Mika
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City U
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村木 克彦
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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Ishii Yoko
大分医科大学臨床薬理学
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Ohya Susumu
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Kitsukawa Mika
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe M
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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