Diverse Expression of Delayed Rectifier K^+ Channel Subtype Transcripts in Several Types of Smooth Muscles of the Rat
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概要
- 論文の詳細を見る
Diverse expression of voltage dependent K^+(Kv)channels was examined in smooth muscles(SMs) ; carotid artery(CA), mesenteric artery(MA), urinary bladder(UB), and vas deferens(VD)of the rat, using RT-PCR based analyses. Among eight Kv channel subtypes examined(Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv2.1, Kv2.2, Kv3.1, and Kv3.2), expression of three delayed rectifier Kv(K_D)channel(Kv1.2, Kv1.5, and Kv2.1)transcripts was observed in these SMs. To determine precisely the expression levels of the transcripts encoding K_D subtypes, those of three K_D subtypes(Kv1.2, Kv1.5, and Kv2.1)were determined by competitive PCR. In vascular SM tissues, CA and MA, Kv1.2 and Kv1.5 transcripts were expressed at relatively high levels. whereas in visceral SM tissues, UB and VD, Kv2.1 transcripts were expressed at the relatively high levels. These results suggest that the diverse expression of K_D subtypes is, at least in part, responsible for differences in electrical excitability and also for the variation of the electrophysiological and pharmacological phenotypes as tonic and phasic SMs.
- 日本平滑筋学会の論文
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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WATANABE Minoru
Department of Pharmacology, St. Marianna University School of Medicine
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Ishii Yoko
大分医科大学臨床薬理学
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Ohya Susumu
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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TANAKA Mamiko
Department of Molecular and Cellular Parmacology, Faculty of Pharmaceutical Sciences, Nagoya City Un
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Tanaka Mamiko
Department Of Molecular And Cellular Parmacology Faculty Of Pharmaceutical Sciences Nagoya City Univ
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe M
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City Uni
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