Electrical Stimulation Prolongs the Survival Days of Leukemic MiceTreated With Methotrexate
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概要
- 論文の詳細を見る
To investigate effects of electrical stimulation on survival days of leukemic mice treated with methotrexate (MTX), L1210-bearing mice were treated by MTX and calcium folinate (leucovorin®) rescue therapy (MTX: 400 mg/kg, followed by leucovorin at the dose of 7.5 mg/kg at 8, 15 and 24 hr after MTX) under electrical stimulation (foot shock: shock amplitude, 0.4 mA; voltage, 60 - 100 V/cm; shock duration, 5 sec; frequency, 0.5 Hz) of various lengths. The survival days were significantly prolonged by 6-hr electrical stimulation in combination with MTX, while plasma MTX concentrations and pharmacokinetic parameters such as the area under the curve (AUC0 - 12 hr) and clearance (CL) were not significantly altered. Psychological stress did not alter the efficacy of MTX in the communication box paradigm. Amplified efficacy of MTX was shown in a length-dependent manner when electrical stimulation of various lengths were applied to L1210-bearing mice.
- 社団法人 日本薬理学会の論文
- 1999-03-01
著者
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Nakamura Koichi
Department of Material Physics, Faculty of Engineering Science, Osaka University
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Nakano Shigeyuki
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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NAKAMURA Koichi
Nagoya Institute of Technology
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UEMURA Naoto
大分医科大学臨床薬理学
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Ishii Yoko
大分医科大学臨床薬理学
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Matsukubo S
Department Of Clinical Pharmacology And Therapeutics
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Nyu Seiji
Department Of Clinical Pharmacology And Therapeutics
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Ishii Yoko
Department Of Pathology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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UEMURA Naoto
Department of Clinical Pharmacology and Therapeutics
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MATSUKUBO Seiichiro
Department of Clinical Pharmacology and Therapeutics
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Nakamura Koichi
Department Of Imaging Art
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Nakamura Koichi
Department Of Clinical Pharmacology And Therapeutics Oita University Faculty Of Medicine
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Ishii Yoko
Department Of Food And Nutrition Japan Women's University
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Ishii Yoko
Department of Electronical Engineering and Bioscience, School of Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan
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Nakamura Koichi
Department of Chemistry, Faculty of Science, Hokkaido University
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