EFFECTS OF CALCIUM BLOCKERS AND Mn^<2+> ON THE RESPONSE OF ISOLATED RAT IRIS SPHINCTER AND DILATOR MUSCLES TO AGONISTS AND Ca^<2+>
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概要
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Effects of calcium blockers and Mn on the mechanical response of the isolated rat iris sphincter and the dilator were investigated. The contraction of the sphincter in response to acetylcholine, the contraction of the dilator in response to norepinephrine and the relaxation-contraction of the dilator in response to acetylcholine and also resting tone of dilator muscle were strongly dependent to external Ca concentration to different extents, while these responses and the tone were scarcely affected by calcium blockers, D-600,diltiazem (all 1μM), or nitroprusside Na (0.1mM). In depolarized sphincter muscle (in the presence of atropine and phentolamine), the contraction induced by externally added Ca was reduced moderately by the Ca-blockers but this effect was far weaker than that expected from their effect on other smooth muscles. Mn (0.3 mM) moderately reduced the calcium contraction of depolarized sphincter. In depolarized dilator muscle, the contraction induced by Ca was not inhibited effectively by any of these Ca blockers but was moderately reduced by Mn. It is suggested that the rat iris muscles are resistant to "organic Ca-blockers" but sensitive to Mn, an "inorganic Ca-blocker".
- 公益社団法人日本薬学会の論文
著者
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Narita Satoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University:(prese
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Narita Satoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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