TOXICOLOGICAL STUDIES ON THE CHLOROQUINE-MELANIN AFFINITY IN VIVO AND IN VITRO IN RELATION TO THE CHLOROQUINE RETINOPATHY
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概要
- 論文の詳細を見る
Using whole body- and micro-radioautography it was found that radio-activity was specifically retained for more than a month following an i.v. injection of ^<14>C-chloroquine in the retinal pigment epithelium of pigmented rats and guinea-pigs, but not in that of albino animals. By a long term oral administration of chloroquine the intensive accumulation of melanin granules in the pigment epithelium and also in the choroid of the pigmented guinea-pig was observed. Using synthetic melanin, chloroquine was found to be adsorbed by melanin in two modes; one operates in low chloroquine concentrations and is extremely strong and independent to pH, and the other operates in higher chloroquine concentrations and is pH-dependent and chloroquine can be released by washing.
- 日本トキシコロジー学会の論文
- 1976-01-15
著者
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Yutaka
Department Of Toxicology And Pharmacology Research Institute For Chemical Hazards Faculty Of Pharmac
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Miyata Hiroshi
Department Of Toxicology And Pharmacology Research Institute For Chemical Hazards Faculty Of Pharmac
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Miyata Hiroshi
Department Of Pediatrics Kinki University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Toxicology And Pharmacology Research Institute For Chemical Hazards Faculty Of Pharmac
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Miyata Hiroshi
Department Of Electric And Electronics Graduate School Of Information Science And Electrical Enginee
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