Effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine.
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概要
- 論文の詳細を見る
The effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine were examined in rats. Chronic co-administration of L-tryptophan with dihydrocodeine prevented the development of tolerance to the antitussive effects of dihydrocodeine. Furthermore, the antitussive effects of dihydrocodeine in dihydrocodeine-tolerant rats were fully restored by acute co-administration of L-tryptophan, as evidenced by a decrease of about 50% in the ED<SUB>50</SUB> value of dihydrocodeine. Thus, it is concluded that L-tryptophan may antagonize the development of tolerance to the antitussive effects of dihydrocodeine.
- 公益社団法人 日本薬理学会の論文
著者
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Mori Tomoko
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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