Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice
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概要
- 論文の詳細を見る
The antinociceptive effect of mexiletine in diabetic mice was examined.Tail−flick latencies at heat intensity of 35 and 50 V in diabetic mice were shorter than those in non−diabetic mice.In diabetic mice, mexiletine increased the tail−flick latency at 35 V to the level observed in non−diabetic mice.The tail−flick latency at 50 V in diabetic mice, but not in non−diabetic mice, was increased by pretreatment with capsaicin(0.56 nmol, i.t., 24 h).The antinociceptive effect of mexiletine in diabetic mice was reduced by capsaicin.These results suggest that the mexiletine−induced antinociception in diabetic mice involves the inhibition of the nociceptive transmission of capsaicin−sensitive primary afferent fibers.
- 社団法人 日本薬理学会の論文
- 2000-09-01
著者
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KAMEI Junzo
Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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Kamei Junzo
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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ZUSHIDA Ko
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
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Zushida Ko
Department Of Pathophysiology And Therapeutics Faculty Of Pharmaceutical Sciences Hoshi University
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