Changes in Emotional Behavior of Mice in the Hole-Board Test After Olfactory Bulbectomy
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概要
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The most consistent behavioral change caused by olfactory bulbectomy (OBX) is a hyperemotional response to novel environmental stimuli. The aim of this study was to characterize the emotional behavior of OBX mice using the hole-board test. After the olfactory bulbs were lesioned, sham and OBX mice were housed in single cages for 14 days. The number of head-dips in the hole-board test in single-housed OBX mice was significantly greater than that in single-housed sham mice. The head-dipping behaviors in single-housed sham and OBX mice were reversed by treatment with diazepam, a typical benzodiazepine anxiolytic. (±)-8-Hydroxy-2-(di-n-propylamino) tetraline hydrobromide (8-OH-DPAT), a selective 5-HT1A-receptor agonist that has a non-benzodiazepine anxiolytic-like effect, and (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethyl benzamide (SNC80), a δ-opioid-receptor agonist, also significantly reversed the number of head-dips in single-housed sham and OBX mice. In conclusion, we suggest that the single-housed OBX mice showed heightened emotional behavior (e.g., increase in head-dipping behavior) in the hole-board test. In addition, we suggest that the hyperemotional behavior characterized by head-dipping behavior in OBX mice was selectively reversed by benzodiazepine and non-benzodiazepine anxiolytics.
- 公益社団法人 日本薬理学会の論文
著者
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Saitoh Akiyoshi
Department Of Pathophysiology & Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hosh
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OKA Takuma
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi
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Hirose Noritaka
Department Of Pathophysiology And Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hoshi
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Yamada Misa
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Nozaki Chihiro
Department Of Biochemistry Meiji Pharmaceutical University
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Yamada Mitsuhiko
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Kamei Junzo
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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Saitoh Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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Saitoh Akiyoshi
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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Hirose Noritaka
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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Yamada Mitsuhiko
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan
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Oka Takuma
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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Nozaki Chihiro
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Japan
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