Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective .DELTA.-Opioid Agonist, in Behavioral Models in Rodents
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概要
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In the present study, we investigated the antidepressant- and anxiolytic-like effects of (+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80), a non-peptidic selective δ-opioid receptor agonist, in various animal models in rodents. SNC80 significantly reduced the duration of immobility in the forced swimming test. Furthermore, in the elevated plus-maze test, SNC80 dose-dependently and significantly increased the time spent in the open arms of the plus-maze. These effects were completely antagonized by a selective δ-opioid-receptor antagonist, naltrindole. In the conditioned fear stress test, which examines psychological stress-induced motor suppression, desipramine did not produce any significant effect on the conditioned suppression of locomotor activity. However, SNC80 completely attenuated the conditioned suppression of locomotor activity in the conditioned fear stress test. In conclusion, our results suggest that δ-opioid receptors may play an important role in the regulation of emotional responses. Furthermore, it is possible that δ-opioid-receptor agonists might be novel and potent antidepressants that also have anxiolytic-like effects.
- 公益社団法人 日本薬理学会の論文
著者
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Nagase Hiroshi
Pharmaceutical Research Laboratories Toray Industries Inc.
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Kawai Koji
Pharmaceutical Research Laboratories Toray Industries Inc.
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Saitoh Akiyoshi
Department Of Pathophysiology & Therapeutics School Of Pharmacy And Pharmaceutical Sciences Hosh
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SUZUKI Tomohiko
Pharmaceutical Research Laboratories, Toray Industries, Inc.
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Kamei Junzo
Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit
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Kimura Yuji
Pharmaceutical Research Laboratories Toray Industries Inc.
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Kamei Junzo
Department of Pathophysiology & Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
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Saitoh Akiyoshi
Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Japan
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