Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.

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概要

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• Effects of highly selective δ-opioid receptor antagonists on the morphine-induced place preference in ddY and μ<SUB>1</SUB>-opioid receptor deficient CXBK mice were investigated. Pretreatment with naltrindole (NTI: a non-selective δ-opioid receptor antagonist), 7-benzylidenenaltrexone (BNTX: a selective δ<SUB>1</SUB>-opioid receptor antagonist) or naltriben (NTB: a selective δ<SUB>2</SUB>-opioid receptor antagonist) abolished the morphine-induced place preference in ddY mice in a dose-dependent manner. These findings suggest that the morphine-induced place preference may be mediated by both δ<SUB>1</SUB> and δ<SUB>2</SUB>-opioid receptors. On the other hand, in μ<SUB>1</SUB>-opioid receptor deficient CXBK mice, pretreatment with these selective δ-opioid receptor antagonists did not affect the morphine-induced place preference, although pretreatment with β-funaltrexamine (β-FNA: a selective μ-opioid receptor antagonist) significantly inhibited the morphine-induced place preference. [D-Pen<SUP>2</SUP>, D-Pen<SUP>5</SUP>]enkephalin (DPDPE: a δ<SUB>1</SUB>-opioid receptor agonist) and [D-Ala<SUP>2</SUP>, Glu<SUP>4</SUP>]deltorphin (deltorphin II: a δ<SUB>2</SUB>-opioid receptor agonist) induced a significant place preference in ddY mice, but not in CXBK mice. These results suggest that δ<SUB>1</SUB>- and δ<SUB>2</SUB>-opioid receptors in the nucleus accumbens that are related to the DPDPE- and deltorphin II-induced place preference may be dysfunctional and/or poor in CXBK mice. These findings also indicate that δ<SUB>1</SUB>- and δ<SUB>2</SUB>-opioid receptors may be involved in the modulation of the reinforcing effect of morphine.

• 公益社団法人 日本薬理学会の論文

著者

• Misawa Miwa

  Department Of Applied Pharmacology Hoshi University

• Kamei Junzo

  Department Of Pathophysilology & Therapeutics Faculty Of Pharmaceutical Sciences Hoshi Universit

• Mizoguchi Hirokazu

  Department Of Anesthesiology Medical College Of Wisconsin

• Nagase Hiroshi

  Basic Research Laboratories Toray Industries Inc.

• Suzuki Tsutomu

  Department Of Applied And Environmental Chemistry Kitami Institute Of Technology

• KAMEI Junzo

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Yoshiike Michiharu

  Department of Pharmacology, School of Pharmacy, Hoshi University

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