Effects of Antiallergic Drugs on Bronchial and Cutaneous Anaphylaxes in Lewis Rats
スポンサーリンク
概要
- 論文の詳細を見る
Effects of antiallergic agents on 2,4-dinitrophenylated Ascaris extract (DNP-As)-induced bronchial asthma were studied in Lewis rats, and compared with those on passive cutaneous anaphylaxis (PCA). Effects of methysergide and chlorpheniramine on the bronchial asthma model were also investigated. Rats were actively sensitized with DNP-As antigen and with killed Bordetella pertussis. After 8 d, asthmatic response was provoked by inhalation of DNP-As. The bronchomotor response was measured with a modified Konzett-Rossler method in diaphragm-sectioned rats. The inhalation of DNP-As caused a marked asthmatic bronchoconstriction without significant effect on systemic blood pressure and heart rate. Disodium cromoglycate (DSCG), 10 mg/kg, i.v., trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) and tranilast at doses of 30 and 100 mg/kg, intraduodenally, significantly inhibited the asthmatic response. Chlorpheniramine and methysergide at a dose of 1 mg/kg, i.v. also significantly inhibited it. The above doses of NCO-650 and tranilast significantly inhibited 48 h PCA, while DSCG almost abolished the PCA. These results indicate that 1) NCO-650 and tranilast inhibited both the asthmatic response and PCA in almost the same degree, 2) DSCG inhibited PCA much more strongly than asthmatic response, and 3) histamine and 5-hydroxytryptamine may be involved in this asthmatic response.
- 公益社団法人日本薬学会の論文
著者
-
Misawa Miwa
Department Of Applied Pharmacology Hoshi University
-
Yanaura S
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
-
Yoshino Yasushi
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
-
Misawa Miwa
星薬科大学 薬 応用薬理
-
Yanaura Saizo
Department Of Pharmacology Hoshi College Of Pharmacy
-
TAKENOUCHI Kiyoteru
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
-
KAMISHIRO Toshiro
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
-
Takenouchi Kiyoteru
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
-
Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
-
Kamishiro T
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
-
YANAURA Saizo
Department of Applied Pharmacology, School of Pharmacy, Hoshi University:Research Institute of Nippon Chemiphar, Co., Ltd.
関連論文
- Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma
- BIOCHEMICAL ASPECTS IN THE EXPERIMENTAL BARBITAL DEPENDENCE IV : ITS EFFECT ON THE HEXOKINASE AND PHOSPHOFRUCTOKINASE ACTIVITIES IN THE RAT BRAIN
- STUDIES ON DRUG DEPENDENCE (Report 87) : Biochemical aspects of experimental barbital dependence. Effect on neural energy and gluco-metabolizing system
- BIOCHEMICAL ASPECTS OF PENTYLENETETRAZOLE INDUCED SEIZURE
- BIOCHEMICAL ASPECTS OF EXPERIMENTAL BARBITAL DEPENDENCE III : EFFECT ON NEURAL ENERGY RESERVE SYSTEM
- WS1-2-1 Prognostic Factors of Bladder Tumor Recurrence after Laparoscopic Radical Nephroureterectomy for Upper Urinary Transitional Cell Carcinoma(Urothelial Cell Cancer)
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- Augmentation of Endothelin-1-Induced Phosphorylation of CPI-17 and Myosin Light Chain in Bronchial Smooth Muscle from Airway Hyperresponsive Rats(Pharmacology)
- INTERACTION BETWEEN MU AND KAPPA RECEPTORS IN PHARMACOLOGICAL EFFECTS OF TOLERANCE TO AND DEPENDENCE ON SEVERAL OPIOIDS
- SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
- Mechanism of Inhibitory Effect of Prednisolone on RhoA Upregulation in Human Bronchial Smooth Muscle Cells
- Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
- Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells
- Functional importance of the cytoskeletal protein in acetylcholine-induced contraction of rat bronchial smooth muscle
- Glucocorticoids Ameliorate Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness by Inhibiting Upregulation of RhoA in Rats
- Increased expression of Gαq protein in bronchial smooth muscle of mice with allergic bronchial asthma
- Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine
- Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo
- Increase in the Expression of Matrix Metalloproteinase-12 in the Airways of Rats with Allergic Bronchial Asthma(Pharmacology)
- Effects of Repeated Antigen Exposure on Endothelin-1-Induced Bronchial Smooth Muscle Contraction and Activation of RhoA in Sensitized Rats
- Involvement of M_3 Muscarinic Receptors in ACh-Induced Increase in Membrane-Associated RhoA of Rat Bronchial Smooth Muscle(Pharmacology)
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- TNF-α augments the expression of RhoA in the rat bronchus
- Upregulation of rhoA mRNA in Bronchial Smooth Muscle of Antigen-induced Airway Hyperresponsive Rats
- Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness
- Involvement of multiple PKC isoforms in phorbol 12,13-dibutyrate-induced contraction during high K^+ depolarization in bronchial smooth muscle of mice
- A NEW SCREENING METHOD FOR EVALUATING ANTITUSSIVES IN CONSCIOUS GUINEA PIGS
- HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
- DRUG EFFECTS ON ELECTRICAL ACTIVITIES OF THE CANINE TRACHEAL CILIATED CELLS
- DIRECT EFFECTS OF EXPECTORANTS ON THE TRACHEOBRONCHIAL SYSTEM IN VIVO
- EFFECTS OF SOME DRUGS ON THE IMMUNE RESPONSE IN THE RESPIRATORY TRACT
- Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
- Interaction between Discriminative Stimulus Effects of Cocaine and Morphine
- Autopsy case of duodenal obstruction from impacted mushroom
- ASSESSMENT OF LEFT INTERNAL MAMMARY ARTERY BYPASS GRAFT PATENCY BY DOPPLER ECHOGRAPHY : THE EXAMINATION FROM LEFT SUPRACLAVICULAR FOSSA : Echocardiography, Pulsed Doppler : 53 Annual Scientific Meeting, Japanese Circulation Society
- The Effect of Platelet-Activating Factor on Histamine Release from Guinea Pig Peritoneal Mast Cells
- Early experience of laparoscopic radical nephrectomy for T3b renal cell carcinoma
- Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats
- How can we safely use ultrasonic laparoscopic coagulating shears?
- The Influence of Megnetic Plugging on RF Plasma Density
- EFFECTS OF NIFEDIPINE ON PHYSICAL DEPENDENCE ON BARBITAL OR DIAZEPAM IN RATS
- The role of RhoA-mediated Ca^ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness
- Advantage of Cine-MR Imaging for the Evaluation of Valvular Regurgitation : 53th Annual Scientific Session of the Japanese Circulation Society
- Effects of κ-Agonist on the Antinociception and Locomotor Enhancing Action Induced by Morphine in Mice
- Identification and Characterization of Rat RhoA Gene Promoter
- Effects of Antiallergic Drugs on Bronchial and Cutaneous Anaphylaxes in Lewis Rats
- EFFECTS OF EXPECTORANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF β-ADRENOCEPTOR STIMULANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF QUINIDINE AND CIMETIDINE ON METHAMPHETA MINE STEREOTYPY IN RATS
- CONTINUOUS DETERMINATION OF TRACHEOBRONCHIAL SECRETORY ACTIVITY IN DOGS
- Abnormal Modulation of Cholinergic Neurotransmission by Endogenous Nitric Oxide in the Bronchus of Rats with Hyperresponsiveness Induced by Allergen Challenge
- Amyloid β Peptide Specifically Promotes Phosphorylation and Nuclear Translocation of the Extracellular Signal-Regulated Kinase in Cultured Rat Cortical Astrocytes
- The Induction of Long-Term Potentiation at Amygdalo-Hippocampal Synapses in Vivo(Pharmacology)
- Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α-Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
- RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
- Ewing's sarcoma/primitive neuroectodermal tumor of the prostate
- Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin
- Activation of signal transducer and activator of transcription factor 1 by interleukins-13 and -4 in cultured human bronchial smooth muscle cells
- Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice
- EFFECTS OF 8-(2-FLUOROETHYL)-3α-HYDROXY-lαH, 5αH-TROPANIUMBROMIDE BENZILATE (Ba598Br) ON ALLERGY AND DRUG-INDUCED ASTHMAS
- ANALYSIS OF EFFERENT DISCHARGES OF THE PHRENIC NERVE DURING THE COUGH REFLEX
- PERIPHERAL EFFECTS OF MORPHINE AND CODEINE ON THE COUGH REFLEX
- EXPECTORANT EFFECT OF BROMHEXINE DERIVATIVES
- HISTOLOGICAL AND HISTOCHEMICAL ANALYSIS OF EXPECTORANT EFFECT
- A ROLE OF LYSOSOMAL ENZYMES IN THE MECHANISM OF MUCOLYTIC ACTION OF BROMHEXINE
- BEHAVIOR OF MUCUS GLYCOPROTEINS OF TRACHEAL SECRETORY CELLS FOLLOWING L-CYSTEINE METHYL ESTER TREATMENT
- EFFECT OF PILOCARPINE ON BEHAVIOR OF MUCUS GLYCOPROTEINS OF CANINE TRACHEAL SECRETORY CELLS
- P-II-5 The Effect of Methamphetamine and Caffeine on Place Preference Conditioning(日本動物心理学会第50回大会発表)
- Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats
- Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats
- Amyloid β protein enhances the clearance of extracellular _L-glutamate by cultured rat cortical astrocytes
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- Phosphorylation of Signal Transducer and Activator of Transcription 6 (STAT6) and STAT1, but Not STAT3, Induced by Antigen Inhalation in Bronchial Smooth Muscles of Sensitized Mice
- MicroRNAs and Their Therapeutic Potential for Human Diseases : MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma
- SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
- RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
- Identification of PKC isoforms expressed in human bronchial smooth muscle cell
- Editorial Comment to Novel posterior reconstruction technique during robot-assisted laparoscopic prostatectomy : Description and comparative outcomes
- Inhibitory Reflex during Bronchoconstrictions Induced by Histamine and Ascaris Suum Antigen.
- The effect of trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) on Ascaris suum antigen-induced bronchoconstriction in dogs.
- Strain difference in an allergic asthma model in rats.
- Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells
- Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression
- Pretreatment of Renal Supscapular Administration of Adipose Tissue-derived Stem Cells Ameliorate Ischemia-reperfusion-Induced Acute Kidney Injury [Innovation in Transplant and Regenerative Medicine. The 13th Meeting of Hirosaki International Forum of Medi
- Analysis of the vagal reflex tracheal constriction in the dog.
- A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.
- Synthetic polycations, polyethylenimines and polyallylamines release histamine from rat mast cells.
- Antitussive effect of RU-20201 - Central and peripheral actions.
- The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference.
- The role of vagal reflex in mechanism of secretagogic action of bromhexine.
- Involvement of inhibitory innervation in reflex tracheal dilatation induced by lung inflation.
- Platelet-activating factor(PAF)-induced rhinitis and involvement of PAF in allergic rhinitis in guinea pigs.
- Effects of bromhexine on the secretions of saliva and tears.
- The effect of platelet-activating factor on histamine release from rat peritoneal mast cells.
- Comparison of histamine release induced by synthetic polycations with that by compound 48/80 from rat mast cells.
- Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.
- Cross-physical dependence of several drugs in methaqualone-dependent rats.
- Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.
- Genetic differences in preferences for morphine and codeine in Lewis and Fischer 344 inbred rat strains.
- The post-operative pathological prognostic parameters of clear cell renal cell carcinoma in pT1a cases